Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 123, Issue -, Pages 236-255Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2016.07.056
Keywords
Coumarin; Antiviral; Anti-HIV; Anti-HCV; Anti-influenza; Anti-herpes
Categories
Funding
- School of Chemical Science, Universiti Sains Malaysia, Penang
- [FRGS/203/6711462]
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Coumarins have received a considerable attention in the last three decades as a lead structures for the discovery of orally bioavailable non-peptidic antiviral agents. A lot of structurally diverse coumarins analogues were found to display remarkable array of affinity with the different molecular targets for antiviral agents and slight modifications around the central motif result in pronounced changes in its antiviral spectrum. This manuscript thoroughly reviews the design, discovery and structure-activity relationship studies of the coumarin analogues as antiviral agents focusing mainly on lead optimization and its development into clinical candidates. (C) 2016 Elsevier Masson SAS. All rights reserved.
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