Journal
MATERIALS LETTERS
Volume 291, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.matlet.2021.129514
Keywords
Bilayer membrane; Hydroxyapatite; Collagen; Tensile strength; Interface
Funding
- JSPS KAKENHI [JP15H03526]
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Hydroxyapatite (HAp) and collagen (Col) composites have been successfully fabricated as bilayer membranes with distinct layer-by-layer structures and robust mechanical properties using a combination of sequential self-assembly and ethanol-exchanged methods. The membranes exhibited HAp embedded in Col fibrils, with sequentially self-assembled membranes showing distinct HAp/Col layers and simultaneously self-assembled membrane having a continuous interface.
Hydroxyapatite (HAp) and collagen (Col) composites have been investigated as bilayer membranes for the application of guided bone regeneration. This study investigated the fabrication of HAp/Col bilayer membranes with different weight ratios based on the sequential or simultaneous Col self-assembly, and ethanol-exchanged methods. The membranes exhibited HAp embedded in Col fibrils. The sequen-tially self-assembled membranes showed distinct HAp/Col layers interconnected by interfaces consisting of elongated collagen fibrils. In contrast, the simultaneously self-assembled membrane had a continuous interface. The bilayer membranes had a tensile strength in the range of 8-50 MPa, depending on the HAp/ Col ratio. The combination of sequential self-assembly and ethanol-exchanged methods is successful in fabricating HAp/Col bilayer membranes with distinct layer-by-layer structures and robust mechanical properties. (c) 2021 Elsevier B.V. All rights reserved.
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