Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 110, Issue -, Pages 13-31Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2015.12.017
Keywords
N-substituted pyrrole; Fused pyrroles; Natural pyrrole derivatives; Therapeutic agents
Categories
Funding
- UGC, New Delhi
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Pyrrole derivatives comprise a class of biologically active heterocyclic compounds which can serve as promising scaffolds for antimicrobial, antiviral, antimalarial, antitubercular, anti-inflammatory and enzyme inhibiting drugs. Due to their inimitable anticancer and anti-tubercular properties, researchers were inspired to develop novel pyrrole derivatives for the treatment of MDR pathogens. In the present review the main target is to focus on the development of pyrrole mimics, with emphasis based on their structure activity relationship (SAR). The present review is being obliging for the future development of pyrrole therapeutics. (C) 2015 Elsevier Masson SAS. All rights reserved.
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