Journal
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
Volume 34, Issue 5, Pages 649-658Publisher
SPRINGER
DOI: 10.1007/s10334-021-00927-y
Keywords
Peripheral arterial disease; Magnetic resonance angiography; Computed tomography angiography
Funding
- NIH NHLBI [R01 HL130093]
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The 3D prototype thin-slab stack-of-stars (tsSOS) quiescent-interval slice-selective (QISS) MRA technique showed better image quality for branch vessels compared to the standard 2D-QISS technique in diagnosing peripheral artery disease (PAD). However, there was no significant difference in objective image quality between the two techniques.
Objective To evaluate the potential clinical benefit of the superior spatial resolution of 3D prototype thin-slab stack-of-stars (tsSOS) quiescent-interval slice-selective (QISS) MRA over standard 2D-QISS MRA for the detection peripheral artery disease (PAD), using computed tomography angiography (CTA) as reference. Materials and methods Twenty-three patients (70 +/- 8 years, 18 men) with PAD who had previously undergone run-off CTA were prospectively enrolled. Patients underwent non-contrast MRA using 2D-QISS and tsSOS-QISS at 1.5 T. Eighteen arterial segments were evaluated for subjective and objective image quality (normalized signal-to-noise, nSNR), vessel sharpness, and area under the curve (AUC) for > 50% stenosis detection. Results Overall subjective image quality ratings for the entire run-off were not different between tsSOS-QISS and 2D-QISS (3 [3; 4] vs 4 [3; 4], respectively; P = 0.813). Sharpness of primary branch vessels demonstrated improved image quality using tsSOS-QISS compared with 2D-QISS (4 [3; 4] vs 3 [2; 3], P = 0.008). Objective image quality measures were not different between 2D-QISS and tsSOS-QISS (nSNR 5.0 +/- 1.9 vs 4.2 +/- 1.8; P = 0.132). AUCs for significant stenosis detection by tsSOS-QISS and 2D-QISS were 0.877 and 0.856, respectively (P = 0.336). Discussion The prototype 3D tsSOS-QISS technique provides similar accuracy in patients with PAD to a standard commercially available 2D-QISS technique, indicating that the use of relatively thick slices does not limit the diagnostic performance of 2D-QISS. However, subjective image quality for branch vessel depiction is improved using the 3D approach.
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