Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 86, Issue 3, Pages 1734-1745Publisher
WILEY
DOI: 10.1002/mrm.28772
Keywords
body imaging; carbon-3 MRI; multinuclear imaging; RF coils; sodium-23 MRI
Funding
- Cancer Research UK (CRUK) [C19212/A16628, C19212/A27150]
- European Union`s Horizon 2020 Research and Innovation Programme [76121]
- National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre [BRC-1215-20014]
- Addenbrooke's Charitable Trust
- CRUK Cambridge Centre [C9685/A25177]
- GlaxoSmithKline
- CRUK & Engineering and Physical Science Research Council (EPSRC) Cancer Imaging Centre in Cambridge and Manchester [C197/A16465]
- Mark Foundation for Cancer Research
- Evelyn Trust
- CRUK National Cancer Imaging Translational Accelerator (NCITA) [C42780/A27066]
- Cambridge University Hospitals NHS Foundation Trust
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The study introduced a quadrature-driven Na-23 birdcage coil for abdominal imaging, which showed improved FOV and B-1(+) uniformity compared to the clamshell coil design. The combination of an 8-channel C-13 receive array with the Na-23 birdcage coil resulted in a significant increase in SNR for Na-23 imaging in the central abdomen.
Purpose: An unmet need in carbon-13 (C-13)-MRI is a transmit system that provides uniform excitation across a large FOV and can accommodate patients of wide-ranging body habitus. Due to the small difference between the resonant frequencies, sodium-23 (Na-23) coil developments can inform C-13 coil design while being simpler to assess due to the higher naturally abundant Na-23 signal. Here we present a removable Na-23 birdcage, which also allows operation as a C-13 abdominal coil. Methods: We demonstrate a quadrature-driven 4-rung Na-23 birdcage coil of 50 cm in length for both Na-23 and C-13 abdominal imaging. The coil transmit efficiencies and B-1(+) maps were compared to a linearly driven C-13 Helmholtz-based (clamshell) coil. SNR was investigated with Na-23 and C-13 data using an 8-channel C-13 receive array within the Na-23 birdcage. Results: The Na-23 birdcage longitudinal FOV was > 40 cm, whereas the C-13 clamshell was < 32 cm. The transmit efficiency of the birdcage at the Na-23 frequency was 0.65 mu T/sqrt(W), similar to the clamshell for C-13. However, the coefficient of variation of Na-23-B-1(+) was 16%, nearly half that with the C-13 clamshell. The 8-channel C-13 receive array combined with the Na-23 birdcage coil generated a greater than twofold increase in Na-23-SNR from the central abdomen compared with the birdcage alone. Discussion: This Na-23 birdcage coil has a larger FOV and improved B-1(+) uniformity when compared to the widely used clamshell coil design while also providing similar transmit efficiency. The coil has the potential to be used for both Na-23 and C-13 imaging.
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