Journal
LIFE SCIENCES
Volume 272, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2021.119251
Keywords
SARS-CoV-2; COVID-19; RAGE; HMGB1; Renin-angiotensin system (RAS)
Funding
- Associazione Italiana per la Ricerca sul Cancro [17581]
- Fondazione Cassa di Risparmio di Perugia [2019.0321.026]
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The novel infectious disease COVID-19, caused by SARS-CoV-2, can lead to severe pneumonia and ARDS in 15% of patients. Research suggests that RAS and RAGE play crucial roles in mediating susceptibility and pathological responses in COVID-19 patients.
A novel infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was detected in December 2019 and declared as a global pandemic by the World Health. Approximately 15% of patients with COVID-19 progress to severe pneumonia and eventually develop acute respiratory distress syndrome (ARDS), septic shock and/or multiple organ failure with high morbidity and mortality. Evidence points towards a determinant pathogenic role of members of the renin-angiotensin system (RAS) in mediating the susceptibility, infection, inflammatory response and parenchymal injury in lungs and other organs of COVID-19 patients. The receptor for advanced glycation end-products (RAGE), a member of the immunoglobulin superfamily, has important roles in pulmonary pathological states, including fibrosis, pneumonia and ARDS. RAGE overexpression/hyperactivation is essential to the deleterious effects of RAS in several pathological processes, including hypertension, chronic kidney and cardiovascular diseases, and diabetes, all of which are major comorbidities of SARS-CoV-2 infection. We propose RAGE as an additional molecular target in COVID-19 patients for ameliorating the multi-organ pathology induced by the virus and improving survival, also in the perspective of future infections by other coronaviruses.
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