Journal
LIFE SCIENCES
Volume 273, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2021.119266
Keywords
Intervertebral disc degeneration; Autophagy; Intervertebral disc; Nucleus pulposus
Funding
- Natural Science Foundation of China [31960175]
- Natural Science Foundation of Gansu Province [18JR3RA331]
- Fund Project of the Second Hospital of Lanzhou University [CY2017-MS06]
- Gansu Youth Science and Technology Fund [20JR10RA752]
Ask authors/readers for more resources
Autophagy plays a dual role in intervertebral disc degeneration, as inducing autophagy can slow down the process while excessive autophagy activation-mediated apoptosis may accelerate degeneration.
Autophagy is an evolutionarily conserved intracellular recirculation system that delivers cytoplasmic content to lysosomes for degradation, thereby maintaining metabolism and homeostasis. Recent studies have found that autophagy plays a dual role in intervertebral disc degeneration (IDD). Most studies have shown that inducing autophagy can slow down the process of IDD. A few studies have shown that extensive autophagy activation-mediated apoptosis accelerates IDD. In this review, we describe the pathophysiological characteristics of intervertebral disc (IVD), the mechanism of autophagy and the application of regulating autophagy in the treatment of IDD, hoping to provide a certain theoretical basis for the biotherapy of IDD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available