T-cell-based immunotherapy of acute myeloid leukemia: current concepts and future developments

Acute myeloid leukemia (AML) is a heterogeneous disease linked to a broad spectrum of molecular alterations, and as such, long-term disease control requires multiple therapeutic approaches. Driven largely by an improved understanding and targeting of these molecular aberrations, AML treatment has rapidly evolved over the last 3-5 years. The stellar successes of immunotherapies that harness the power of T cells to treat solid tumors and an improved understanding of the immune systems of patients with hematologic malignancies have led to major efforts to develop immunotherapies for the treatment of patients with AML. Several immunotherapies that harness T cells against AML are in various stages of preclinical and clinical development. These include bispecific and dual antigen receptor-targeting antibodies (targeted to CD33, CD123, CLL-1, and others), chimeric antigen receptor (CAR) T-cell therapies, and T-cell immune checkpoint inhibitors (including those targeting PD-1, PD-L1, CTLA-4, and newer targets such as TIM3 and STING). The current and future directions of these T-cell-based immunotherapies in the treatment landscape of AML are discussed in this review.

Automated summary

AML is a heterogeneous disease with a broad spectrum of molecular abnormalities, requiring multiple therapeutic approaches for long-term disease control. Recent advancements in understanding and targeting these molecular aberrations have led to rapid evolution in AML treatment, with a focus on immunotherapies harnessing T cells. Multiple T-cell-based immunotherapies, including bispecific antibodies, CAR T-cell therapies, and immune checkpoint inhibitors, are in various stages of development for AML treatment.