4.7 Review

GSK-3: a multifaceted player in acute leukemias

Related references

Note: Only part of the references are listed.
Article Cell Biology

GSK3β suppression inhibits MCL1 protein synthesis in human acute myeloid leukemia cells

Yuan-Chin Lee et al.

Summary: This study investigated the mechanism of AR-A014418-induced GSK3 beta suppression in AML therapy. The results showed that AR-A014418-induced MCL1 downregulation triggered apoptosis in U937 cells by activating p38 MAPK and inhibiting Akt and ERK pathways. Additionally, AR-A014418 sensitized U937 cells to ABT-263 cytotoxicity. Overall, the findings suggest that AR-A014418-induced GSK3 beta suppression inhibits de novo MCL1 protein synthesis, leading to apoptosis in U937 cells.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Review Chemistry, Medicinal

PROTACs to address the challenges facing small molecule inhibitors

Pedro Martin-Acosta et al.

Summary: Small molecule inhibitors play important roles in targeting proteins, but face challenges in drug selectivity and therapy resistance. PROTACs are a new class of molecules that can achieve complete target protein degradation in a catalytical fashion.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Oncology

FBW7 Inhibits Myeloid Differentiation in Acute Myeloid Leukemia via GSK3-Dependent Ubiquitination of PU.1

Mukul Mishra et al.

Summary: The study finds that GSK3β kinase inhibition can inhibit AML cell growth and promote myeloid differentiation by phosphorylating PU.1 leading to its degradation, thereby inhibiting monocyte-macrophage differentiation.

MOLECULAR CANCER RESEARCH (2021)

Letter Hematology

PU.1 subcellular localization in acute myeloid leukaemia with mutated NPM1

Giulia Pianigiani et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

Review Biochemistry & Molecular Biology

Emerging roles of GSK-3α in pathophysiology: Emphasis on cardiometabolic disorders

Firdos Ahmad et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)

Review Oncology

A User's Guide to Novel Therapies for Acute Myeloid Leukemia

Shyam A. Patel et al.

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2020)

Review Biochemistry & Molecular Biology

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

Youn-Sang Jung et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Review Biochemistry & Molecular Biology

The Role Played by Wnt/beta-Catenin Signaling Pathway in Acute Lymphoblastic Leukemia

Francesca Chiarini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Cell Biology

Targeting Wnt/β-catenin and PI3K/Akt/mTOR pathways in T-cell acute lymphoblastic leukemia

Cecilia Evangelisti et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

Review Biochemistry & Molecular Biology

Crosstalks of GSK3 signaling with the mTOR network and effects on targeted therapy of cancer

Camilla Evangelisti et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)

Article Biochemistry & Molecular Biology

Improving the Treatment of Acute Lymphoblastic Leukemia

Ashish Radadiya et al.

BIOCHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment

Yongsheng Ruan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Oncology

Targeting CXCR4 in AML and ALL

Daniel Cancilla et al.

FRONTIERS IN ONCOLOGY (2020)

Article Hematology

Targeting transcription factors in acute myeloid leukemia

Hisashi Takei et al.

INTERNATIONAL JOURNAL OF HEMATOLOGY (2019)

Review Oncology

Glycogen synthase kinases: Moonlighting proteins with theranostic potential in cancer

Siddavaram Nagini et al.

SEMINARS IN CANCER BIOLOGY (2019)

Review Cell Biology

WNT Signaling in Cancer Immunosurveillance

Lorenzo Galluzzi et al.

TRENDS IN CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin

Long He et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Cell & Tissue Engineering

In Vitro Expansion of Hematopoietic Stem Cells by Inhibition of Both GSK3 and p38 Signaling

Jing Li et al.

STEM CELLS AND DEVELOPMENT (2019)

Article Multidisciplinary Sciences

Pyrrothiogatain acts as an inhibitor of GATA family proteins and inhibits Th2 cell differentiation in vitro

Shunsuke Nomura et al.

SCIENTIFIC REPORTS (2019)

Review Cell Biology

Signaling Enzymes Required for Sperm Maturation and Fertilization in Mammals

Souvik Dey et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Article Pharmacology & Pharmacy

A partnership with the proteasome; the destructive nature of GSK3

Holly Robertson et al.

BIOCHEMICAL PHARMACOLOGY (2018)

Article Biochemistry & Molecular Biology

mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation

Long He et al.

MOLECULAR CELL (2018)

Article Hematology

Aberrant GSK3β nuclear localization promotes AML growth and drug resistance

James J. Ignatz-Hoover et al.

BLOOD ADVANCES (2018)

Article Medicine, Research & Experimental

Pharmacological inhibition of the transcription factor PU.1 in leukemia

Ileana Antony-Debre et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Review Cell Biology

The Key Roles of GSK-3 beta in Regulating Mitochondrial Activity

Kai Yang et al.

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)

Article Hematology

How should we treat a patient with relapsed Ph-negative B-ALL and what novel approaches are being investigated?

Nicola Goekbuget

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2017)

Review Biochemistry & Molecular Biology

Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer

James A. McCubrey et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Review Hematology

Update on rational targeted therapy in AML

Danielle Shafer et al.

BLOOD REVIEWS (2016)

Article Biochemistry & Molecular Biology

Negative regulation of NF-κB p65 activity by serine 536 phosphorylation

Jean-Philippe Pradere et al.

SCIENCE SIGNALING (2016)

Article Multidisciplinary Sciences

Repression of GSK3 restores NK cell cytotoxicity in AML patients

Reshmi Parameswaran et al.

NATURE COMMUNICATIONS (2016)

Article Education, Scientific Disciplines

T-cell acute lymphoblastic leukemia

Elizabeth A. Raetz et al.

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2016)

Article Biochemistry & Molecular Biology

Negative regulation of NF-κB p65 activity by serine 536 phosphorylation

Jean-Philippe Pradere et al.

SCIENCE SIGNALING (2016)

Article Chemistry, Medicinal

Evaluation of Improved Glycogen Synthase Kinase-3α Inhibitors in Models of Acute Myeloid Leukemia

Theresa Neumann et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Glycogen Synthase Kinase-3β Stabilizes the Interleukin (IL)-22 Receptor from Proteasomal Degradation in Murine Lung Epithelia

Nathaniel M. Weathington et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Clinical Neurology

A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy

Eduardo Tolosa et al.

MOVEMENT DISORDERS (2014)

Article Pharmacology & Pharmacy

Activator or inhibitor? GSK-3 as a new drug target

Fumi Takahashi-Yanaga

BIOCHEMICAL PHARMACOLOGY (2013)

Article Neurosciences

Treatment of Alzheimer's Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study

Teodoro del Ser et al.

JOURNAL OF ALZHEIMERS DISEASE (2013)

Article Cell Biology

The beta-Catenin Destruction Complex

Jennifer L. Stamos et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Review Oncology

GSK-3 and mitochondria in cancer cells

Federica Chiara et al.

FRONTIERS IN ONCOLOGY (2013)

Article Medicine, Research & Experimental

The intersection of genetic and chemical genomic screens identifies GSK-3α as a target in human acute myeloid leukemia

Versha Banerji et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Oncology

GSK3 is a regulator of RAR-mediated differentiation

K. Gupta et al.

LEUKEMIA (2012)

Article Biochemistry & Molecular Biology

Maintenance of hematopoietic stem cells through regulation of Wnt and mTOR pathways

Jian Huang et al.

NATURE MEDICINE (2012)

Review Neurosciences

GSK3 as a sensor determining cell fate in the brain

Adam R. Cole

FRONTIERS IN MOLECULAR NEUROSCIENCE (2012)

Article Cell Biology

GSK3β inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb

Fangfang Zhou et al.

MOLECULAR BIOLOGY OF THE CELL (2011)

Article Multidisciplinary Sciences

Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation

Sejeong Shin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Neurosciences

GSK-3: functional insights from cell biology and animal models

Oksana Kaidanovich-Beilin et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2011)

Article Medicine, Research & Experimental

Characterization of a GSK-3 inhibitor in culture of human cord blood primitive hematopoietic cells

Junfen Jiang et al.

BIOMEDICINE & PHARMACOTHERAPY (2010)

Article Hematology

Glycogen synthase kinase-3β inhibitors suppress leukemia cell growth

Emma Y. Song et al.

EXPERIMENTAL HEMATOLOGY (2010)

Article Biochemistry & Molecular Biology

Suppressive Regulatory T Cell Activity Is Potentiated by Glycogen Synthase Kinase 3β Inhibition

Jay A. Graham et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Subcellular Localization of Glycogen Synthase Kinase 3β Controls Embryonic Stem Cell Self-Renewal

Matthew Bechard et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Medicine, Research & Experimental

Deletion of GSK-3β in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation

Risto Kerkela et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Article Multidisciplinary Sciences

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

Zhong Wang et al.

NATURE (2008)

Article Biochemistry & Molecular Biology

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

K Ito et al.

NATURE MEDICINE (2006)

Article Biochemistry & Molecular Biology

Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation

JJ Trowbridge et al.

NATURE MEDICINE (2006)

Article Biochemistry & Molecular Biology

Glycogen synthase kinase-3β is tyrosine-phosphorylated by MEK1 in human skin fibroblasts

F Takahashi-Yanaga et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Multidisciplinary Sciences

Synthetic small molecules that control stem cell fate

S Ding et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Structural basis for recruitment of glycogen synthase kinase 3β to the axin-APC scaffold complex

R Dajani et al.

EMBO JOURNAL (2003)

Article Biochemistry & Molecular Biology

Expression, localization, and activity of glycogen synthase kinase 3β during mouse skin tumorigenesis

H Leis et al.

MOLECULAR CARCINOGENESIS (2002)

Article Biochemistry & Molecular Biology

Regulation of glycogen synthesis in human muscle cells

SJ Yeaman et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2001)