4.6 Article

Effect of Multilayer Termination on Nonspecific Protein Adsorption and Antifouling Activity of Alginate-Based Layer-by-Layer Coatings

Journal

LANGMUIR
Volume 37, Issue 19, Pages 5950-5963

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.1c00491

Keywords

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Funding

  1. Office of Naval Research (ONR) [N00014-16-12979, N00014-16-1-2988, N00014-16-1-3125]
  2. Deutsche Forschungsgemeinschaft (DFG) [RO2524/4-1]

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Layer-by-layer assembly was used to fabricate alginate-based coatings, investigating the impact of termination on properties and antifouling efficacy. The hydrophilic films showed high swelling in water, reduced protein adsorption, and good antifouling properties. The choice of polycation was crucial for protein resistance, while termination mattered less.
Layer-by-layer (LbL) assembly is a versatile platform for applying coatings and studying the properties of promising compounds for antifouling applications. Here, alginate-based LbL coatings were fabricated by alternating the deposition of alginic acid and chitosan or polyethylenimine to form multilayer coatings. Films were prepared with either odd or even bilayer numbers to investigate if the termination of the LbL coatings affects the physicochemical properties, resistance against the nonspecific adsorption (NSA) of proteins, and antifouling efficacy. The hydrophilic films, which were characterized using spectroscopic ellipsometry, water contact angle goniometry, ATR-FTIR spectroscopy, AFM, XPS, and SPR spectroscopy, revealed high swelling in water and strongly reduced the NSA of proteins compared to the hydrophobic reference. While the choice of the polycation was important for the protein resistance of the LbL coatings, the termination mattered less. The attachment of diatoms and settling of barnacle cypris larvae revealed good antifouling properties that were controlled by the termination and the charge density of the LbL films.

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