Correlates of protection from SARS-CoV-2 infection

Article Infectious Diseases

Genomic evidence for reinfection with SARS-CoV-2: a case study

Richard L. Tillett et al.

Summary: A man was infected with SARS-CoV-2 twice with genetically different virus variants, the second infection being more severe. The study suggests that previous exposure to SARS-CoV-2 may not guarantee immunity, and all individuals should take precautions to avoid infection. This has implications for vaccine development and application.

LANCET INFECTIOUS DISEASES (2021)

Add to Collection

Article Multidisciplinary Sciences

Correlates of protection against SARS-CoV-2 in rhesus macaques

Katherine McMahan et al.

Summary: Adoptive transfer of purified IgG from convalescent macaques protects naive macaques against SARS-CoV-2 infection, and cellular immune responses contribute to protection against rechallenge with SARS-CoV-2. The findings suggest that relatively low antibody titres are sufficient for protection against SARS-CoV-2 in macaques, while higher antibody titres are required for treatment of SARS-CoV-2 infection.

NATURE (2021)

Add to Collection

Article Medicine, General & Internal

Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers

S. F. Lumley et al.

Summary: In a longitudinal study of seropositive and seronegative health care workers undergoing asymptomatic and symptomatic SARS-CoV-2 testing, the presence of anti-spike or anti-nucleocapsid IgG antibodies was associated with a substantially reduced risk of SARS-CoV-2 reinfection in the ensuing 6 months.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Add to Collection

Article Medicine, General & Internal

SARS-CoV-2 re-infection risk in Austria

Stefan Pilz et al.

Summary: According to the study in Austria, the rate of SARS-CoV-2 re-infections is relatively low. Protection against SARS-CoV-2 after natural infection is comparable to the highest estimates of vaccine efficacies.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

Add to Collection

Article Medicine, General & Internal

Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection

Raymond A. Harvey et al.

Summary: Understanding the impact of serum antibodies to SARS-CoV-2 on infection susceptibility is crucial for identifying at-risk populations and vaccine deployment. Results of the study suggest that individuals with positive antibody test results initially had a higher likelihood of positive NAAT results, but this likelihood decreased significantly over time, indicating that seropositivity may be associated with protection from infection, though the duration of this protection remains uncertain and may decrease over time.

JAMA INTERNAL MEDICINE (2021)

Add to Collection

Article Medicine, General & Internal

Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study

Christian Holm Hansen et al.

Summary: The study investigated the protection against SARS-CoV-2 reinfection, with results showing an 80.5% protection rate for individuals previously infected. Even in the population aged 65 years and older, the protection rate against reinfection reached 47.1%, with no significant differences observed by gender or time since infection.

LANCET (2021)

Add to Collection

Article Multidisciplinary Sciences