Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 424, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jns.2021.117421
Keywords
Peripheral neuropathy; Overlap myositis; Sjogren's syndrome; Scleroderma; Rheumatoid arthritis; Systemic lupus erythematosus
Categories
Ask authors/readers for more resources
Rheumatological diseases can cause damage to connective tissue and the peripheral nervous system, leading to peripheral neuropathies and overlap myositis. These conditions have diverse presentations and require prompt recognition and treatment.
Rheumatological diseases result in immune-mediated injury to not only connective tissue, but often components of the peripheral nervous system. These overlap conditions can be broadly categorized as peripheral neuropathies and overlap myositis. The peripheral neuropathies are distinctive as many have unusual presentations such as non-length-dependent, small fiber neuropathies and sensory neuronopathies (both due to dorsal root ganglia dysfunction), multiple mononeuropathies (e.g. vasculitic neuropathies), and even cranial neuropathies. Overlap myositis is increasingly recognized and is often associated with specific autoantibodies. Sarcoidosis also has widespread neurological manifestations and impacts both the peripheral nerves and muscle. Much work is needed to fully characterize the vast presentations of these overlap diseases. Given the rarity of these disorders, they are understudied, resulting in significant knowledge gaps with regards to their underlying pathophysiology and the best treatment approach. A basic knowledge of these disorders is mandatory for both practicing rheumatologists and neurologists as prompt recognition and early initiation of immunotherapy may prevent significant morbidity and permanent disability.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available