Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Metal Complexes and Their Effect at the Cellular Level

The nonsteroidal anti-inflammatory drugs (NSAIDs) make up a great group of drugs that provide benefits in the prevention of cancers. Coordinated metal ions with NSAIDs provide advantages over the drugs themselves. The metal complexes of NSAIDs display a range of biological activities quite often inaccessible to the original NSAID ligands. NSAIDs-metal complexes have molecular properties different from those of the parent drugs. Thus, if a given NSAIDs-metal complex remains intact in the biological medium its biological target is almost invariably different from the original NSAID target. This review includes results obtained on the antibacterial and antiproliferative activities of metal-NSAIDs complexes and their interaction with intracellular components. The study shows that the molecular weights of metal complexes containing the same NSAID are linearly related to their IC50 values against MCF-7 cells. Moreover, compounds with low molecular weight strongly bind to DNA.