An Antibacterial Zn-MOF with Hydrazinebenzoate Linkers

A Zn-based metal-organic framework (MOF) with hydrazinebenzoate linkers was evaluated as antimicrobial material against the Gram-positive bacterium Staphylococcus aureus. The material inhibits bacterial growth and metabolic activity, with a half maximal effective concentration of about 20 mg L-1 material dispersed in the culture medium. The antimicrobial effect can be attributed to the release of the 4-hydrazinebenzoate linker, with a negligible contribution from the free metal. The material exhibits remarkable durability, and it enables the sustained release of the ligand over a period of several days.