Journal
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Volume -, Issue 12, Pages 1785-1791Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejic.201600857
Keywords
Platinum; Lonidamine; Cancer; Cytotoxicity; O ligand
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Funding
- Russian Foundation for Basic Research [16-33-00373, 16-33-60230, 16-03-00743]
- Russian Science Foundation [14-03-00483]
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The synthesis and in vitro cytotoxicity of a series of Pt-IV complexes with lonidamine as a ligand coordinated in axial position are described. Lonidamine was found to affect strongly the in vitro cytotoxic activity of these new complexes, lowering the IC50 values down to the nanomolar range. Lipophilicity assessed in terms of log P showed no direct correlation with cytotoxicity.
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