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Vlad Ratziu et al.
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Travis S. Young et al.
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Takahito Mukai et al.
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Carsten Krieg et al.
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Agnes Mihajlovski et al.
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Tomasz Fekner et al.
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Jiantao Guo et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
One plasmid selection system for the rapid evolution of aminoacyl-tRNA synthetases
Charles E. Melancon et al.
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Jeremy H. Mills et al.
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Wen-Tai Li et al.
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Takatsugu Kobayashi et al.
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PCR with an Expanded Genetic Alphabet
Denis A. Malyshev et al.
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Evolving a Polymerase for Hydrophobic Base Analogues
David Loakes et al.
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Duy P. Nguyen et al.
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Optimization of an Unnatural Base Pair toward Natural-Like Replication
Young Jun Seo et al.
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Diatom plastids depend on nucleotide import from the cytosol
Michelle Ast et al.
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Multistep Engineering of Pyrrolysyl-tRNA Synthetase to Genetically Encode Nε-(o-Azidobenzyloxycarbonyl) lysine for Site-Specific Protein Modification
Tatsuo Yanagisawa et al.
CHEMISTRY & BIOLOGY (2008)
Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet
Aaron M. Leconte et al.
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In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy
Susan E. Cellitti et al.
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A putative new order of methanogenic Archaea inhabiting the human gut, as revealed by molecular analyses of the mcrA gene
Agnes Mihajlovski et al.
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Site-specific incorporation of unnatural amino acids into urate oxidase in Escherichia coli
Mingjie Chen et al.
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PEGylation of somatropin (recombinant human growth hormone): Impact on its clearance in humans
R. Webster et al.
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The amino-terminal domain of pyrrolysyl-tRNA synthetase is dispensable in vitro but required for in vivo activity
Stephanie Herring et al.
FEBS LETTERS (2007)
Evolved orthogonal ribosomes enhance the efficiency of synthetic genetic code expansion
Kaihang Wang et al.
NATURE BIOTECHNOLOGY (2007)
Pyrrolysine is not hardwired for cotranslational insertion at UAG codons
Alexandre Ambrogelly et al.
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Elderly cancer patients receiving chemotherapy benefit from first-cycle pegfilgrastim
Lodovico Balducci et al.
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Clinical applications of granulocyte-colony stimulating factor
Lillian Sung et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2007)
Artificially expanded genetic information system: a new base pair with an alternative hydrogen bonding pattern
Zunyi Yang et al.
NUCLEIC ACIDS RESEARCH (2006)
Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of pyrrolysyl-tRNA synthetase from the methanogenic archaeon Methanosarcina mazei
Tatsuo Yanagisawa et al.
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2006)
Emergent properties of reduced-genome Escherichia coli
G Pósfai et al.
SCIENCE (2006)
Efficient incorporation of unnatural amino acids into proteins in Escherichia coli
YH Ryu et al.
NATURE METHODS (2006)
Polymerase evolution: Efforts toward expansion of the genetic code
AM Leconte et al.
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Aggregation of granulocyte-colony stimulating factor in vitro involves a conformationally altered monomeric state
SW Raso et al.
PROTEIN SCIENCE (2005)
A network of orthogonal ribosome•mRNA pairs
O Rackham et al.
NATURE CHEMICAL BIOLOGY (2005)
The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity
NJ Harmer et al.
BIOCHEMISTRY (2004)
Direct charging of tRNACUA with pyrrolysine in vitro and in vivo
SK Blight et al.
NATURE (2004)
An aminoacyl-tRNA synthetase that specifically activates pyrrolysine
C Polycarpo et al.
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Effect of growth hormone treatment on adult height in peripubertal children with idiopathic short stature: A randomized, double-blind, placebo-controlled trial
EW Leschek et al.
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An expanded genetic code with a functional quadruplet codon
JC Anderson et al.
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Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion
T Kobayashi et al.
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The effect of pegylated human recombinant leptin (PEG-OB) on neuroendocrine adaptations to semi-starvation in overweight men
CJ Hukshorn et al.
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Effect of interleukin-8 and granulocyte colony-stimulating factor on priming and activation of bovine neutrophils
GB Mitchell et al.
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CJ Hukshorn et al.
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Addition of the keto functional group to the genetic code of Escherichia coli
L Wang et al.
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A randomized double-blind multicenter phase III study of fixed-dose single-administration pegfilgrastim versus daily filgrastim in patients receiving myelosuppressive chemotherapy
MD Green et al.
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An efficient system for the evolution of aminoacyl-tRNA synthetase specificity
SW Santoro et al.
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Addition of p-azido-L-phenylaianine to the genetic code of Escherichia coli
JW Chin et al.
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FA Holmes et al.
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A new UAG-encoded residue in the structure of a methanogen methyltransferase
B Hao et al.
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Pyrrolysine encoded by UAG in Archaea: Charging of a UAG-decoding specialized tRNA
G Srinivasan et al.
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Ribosome structure and the mechanism of translation
V Ramakrishnan
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WJ Leonard
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P Nissen et al.
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Expanding the genetic code of Escherichia coli
L Wang et al.
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JM Harris et al.
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L Wang et al.
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