An efficient and green synthesis of 1,4-dihydropyridine derivatives through multi-component reaction in subcritical EtOH

A simple, environmentally friendly and highly efficient method has been developed for the synthesis of 1,4-dihydropyridine compounds. A number of aromatic aldehydes, ethylaceto acetate and urea converted into corresponding in l,4Dihydropyridine derivatives via one-pot multicomponent reaction in sub-critical ethanol. This study shown that 1,4-dihyropyridines can be synthesized in sub-critical ethanol and has the advantage of excellent yields, short reaction time, and simple work-up conditions.

Automated summary

A simple and eco-friendly method has been developed for synthesizing 1,4-dihydropyridine compounds in sub-critical ethanol with excellent yields, short reaction time, and easy work-up conditions.