4.3 Article

TiO2/CeO2-CePO4-decorated enzymatic glucose biosensors operating in oxygen-restrictive environments

Journal

JOURNAL OF SOLID STATE ELECTROCHEMISTRY
Volume 25, Issue 7, Pages 1937-1947

Publisher

SPRINGER
DOI: 10.1007/s10008-021-04956-4

Keywords

Glucose; Ceria; Cerium phosphate; Oxygen-restrictive; Glucose oxidase

Funding

  1. National Key Research and Development Program of China [2018YFC1901202]
  2. NSF of China [81771976]
  3. Fundamental Research Funds for the Central Universities
  4. joint fund of Southeast University and Nanjing Medical University

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The research described a novel system composed of TiO2 and CeO2-CePO4 composite nanostructures to address the oxygen dependence issue in the first-generation amperometric glucose biosensors. The resulting composites showed good electro-catalytic activity towards glucose oxidation and provided a wide linear range for glucose detection, promising increased sensitivity of glucose biosensors.
The detection of glucose plays an important role in monitoring and controlling diabetes as well as its complications caused by high blood glucose levels. There have been a lot of research on glucose sensors and integrated flexible sensing platforms; however, the detection in oxygen-restrictive environments is few reported. Herein, we described the use of a novel system made up of TiO2 and ceria-cerium phosphate (CeO2-CePO4) composite nanostructures synthesized by a simple procedure to address the oxygen dependence problem confronted in the first-generation amperometric glucose biosensors. The enzymatic activity of sensors was tested in both oxygen-rich and restrictive environments. Our results showed that the resulting composites present good electro-catalytic activity towards glucose oxidation. The electrodes decorated by TiO2/CeO2-CePO4 showed a wide linear range from 0.1 to 1.7 mM with a low detection limit of 17.1 mu M while the CeO2-CePO4 showed the linear range of 0.1-2.5 mM with limit of detection of 58.0 mu M in oxygen-rich environment. Two types of decorated electrodes both responded to glucose well under the oxygen-restrictive environment but former showed better response performance. The as-fabricated electrodes also owned the good anti-interference, stability, and reproducibility. This strategy promises for increasing the sensitivity of glucose biosensors and provides more opportunities for operation in oxygen-restrictive conditions.

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