Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 46, Issue 5, Pages 1091-1100Publisher
WILEY
DOI: 10.1002/eji.201545780
Keywords
Cytokines; Immune regulation; Innate immunity; Interleukin-33
Categories
Funding
- Science Foundation Ireland (SFI)
- National Children's Research Centre
- SFI [12/IA/1421]
- SFI Research Centre, Advanced Materials and BioEngineering Research (AMBER) [SFI/12/RC/2278]
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Interleukin (IL)-33, a member of the IL-1 family, was originally described in 2005 as a potent initiator of type 2 immunity found during allergic inflammation and parasitic infections. IL-33 has been shown to play important and potent roles bridging innate and adaptive immunity in the regulation of tissue homeostasis, injury, and repair. Recent discoveries have extended the range of functions for IL-33 beyond type 2 conditions and its role as an alarmin at barrier sites, with emerging central roles for IL-33 in T-cell regulation, obesity, viral and tumor immunity. Here, we review the recent advances on how IL-33 activity is regulated, its immunomodulatory properties on innate and adaptive cells, and the newly discovered roles of IL-33 in obesity, intestinal inflammation, and tumorigenesis.
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