Development of hydrophilic magnetic molecularly imprinted polymers for the dispersive solid-phase extraction of sulfonamides from animal-derived samples before HPLC detection

Highly hydrophilic magnetic molecularly imprinted polymers were prepared through a surface imprinting technique for dispersive solid-phase extraction coupled with high-performance liquid chromatography to detect trace levels of ten sulfonamides in animal-derived samples. The obtained imprinted polymers were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, and adsorption experiments, which exhibited excellent specific adsorption for template sulfamethazine in aqueous solution. Moreover, the adsorption process could be completed within 25 min. Under the optimum conditions, the method exhibits good linear performance in the range of 5-to 10 mg/L, limits of detection ranging from 0.57 to 1.50 mu g/L, and good recoveries of 85.09-110.93% in the spiked samples (chicken, cow milk, and goat milk). The proposed detection method not only avoids the use of organic solvents but also simplifies the pretreatment procedure via excellent magnetic properties. Furthermore, the method shows great potential for the rapid detection of drug residues.

Automated summary

Highly hydrophilic magnetic molecularly imprinted polymers were prepared for the detection of trace levels of sulfonamides in animal-derived samples, showing excellent specific adsorption properties for the target template compound. The method, with good linear performance and high recoveries in spiked samples, avoids the use of organic solvents and simplifies the pretreatment process. This approach holds great potential for rapid detection of drug residues.