Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 46, Issue 3, Pages 531-538Publisher
WILEY
DOI: 10.1002/eji.201545821
Keywords
T-cell development; Thymus; Transcription factors; Transcriptional regulation; Transcriptional network; T-cell progenitors
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Funding
- Grants-in-Aid for Scientific Research [26293109, 15K08535] Funding Source: KAKEN
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T-cell development occurs in multipotent progenitors arriving in the thymus, which provides a highly specialized microenvironment. Specification and sequential commitment processes to T cells begin in early thymic progenitors upon receiving thymus-specific environmental cues, resulting in the activation of the genetically programmed transcriptional cascade that includes turning on and off numerous transcription factors in a precise manner. Thus, early thymocyte differentiation has been an excellent model system to study cell differentiation processes. This review summarizes recent advances in our knowledge on thymic T-cell development from newly arrived multipotent T-cell progenitors to fully committed T-cell precursors, from the transcriptional regulation perspective.
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