Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 46, Issue 5, Pages 1258-1270Publisher
WILEY-BLACKWELL
DOI: 10.1002/eji.201545847
Keywords
CD27; CD11b; Computer simulation; Mathematical model; Natural killer cells
Categories
Funding
- Israel Science Foundation Bikura program [1503/08]
- Human Frontiers Science Program-a Young Investigator Grant
- Swedish Foundation for Strategic Research
- Swedish Research Council
- European Research Council (THINK)
- Equipe Labellisee La Ligue
- INSERM
- CNRS
- Aix-Marseille University
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Murine NK cells can be divided by the expression of two cell surface markers, CD27 and Mac-1 (a.k.a. CD11b), into four separate subsets. These subsets suggest a linear development model: CD27(-) Mac-1(-) -> CD27(+) Mac-1(-) -> CD27(+) Mac-1(+) -> CD27(-) Mac-1(+). Here, we used a combination of BrdU labeling experiments and mathematical modeling to gain insights regarding NK-cell development in mouse bone marrow (BM), spleen and liver. The modeling results that best fit the experimental data show that the majority of NK cells already express CD27 upon entering the NK-cell developmental pathway. Additionally, only a small fraction of NK cells exit the BM to other sites, suggesting that peripheral NK-cell populations originate from site-specific immature NK cells more than from BM-derived mature NK cells.
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