Journal
JOURNAL OF PSYCHIATRIC RESEARCH
Volume 136, Issue -, Pages 265-273Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2021.02.024
Keywords
First episode of psychosis; Network analysis; Functioning
Categories
Funding
- Madrid Regional Government (R&D activities in Biomedicine) [S2017/BMD-3740 - AGES-CM 2-CM]
- Structural Funds of the European Union
- PFIS predoctoral program from the Instituto de Salud Carlos III (Spain) [FI17/00138]
- European Union (ERDF/ESF, A way to make Europe/Investing in your future)
- Biomedical Research Foundation of La Princesa University Hospital
- CIBERSAM
- Spanish Ministry of Science, Innovation and Universities
- ERDF Funds from the European Commission [PI16/00834, PI19/01295]
- Juan Rodes Grant from Instituto de Salud Carlos III [JR19/00024]
- Spanish Ministry of Science and Innovation
- ERDF Funds from the European Commission, A way of making Europe, CIBERSAM [SAM16PE07CP1, PI16/02012, PI19/024]
- Madrid Regional Government [B2017/BMD-3740 AGES-CM-2]
- European Union Seventh Framework Program [FP7-4-HEALTH-2009-2.2.1-2-241909, FP7-HEALTH-2013-2.2.1-2-603196, FP7-HEALTH-20132.2.1-2-602478]
- European Union H2020 Program under the Innovative Medicines Initiative 2 Joint Undertaking [115916, 777394]
- Fundacion Familia Alonso
- Fundacion Alicia Koplowitz
- Fundacion Mutua Madrilena
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The study used network analysis to examine the relationship between symptoms and functioning dimensions in first-episode psychosis (FEP) patients, identifying specific symptoms and functioning dimensions that should be prioritized in clinical assessment and management. These areas may also be targeted for future early intervention strategies to improve quality of life in this population.
The relationship between psychotic symptoms and global measures of functioning has been widely studied. No previous study has assessed so far the interplay between specific clinical symptoms and particular areas of functioning in first-episode psychosis (FEP) using network analysis methods. A total of 191 patients with FEP (age 24.45 ? 6.28 years, 64.9% male) participating in an observational and longitudinal study (AGES-CM) comprised the study sample. Functioning problems were assessed with the WHO Disability Assessment Schedule (WHODAS), whereas the Positive and Negative Syndrome Scale (PANSS) was used to assess symptom severity. Network analysis were conducted with the aim of analysing the patterns of relationships between the different dimensions of functioning and PANSS symptoms and factors at baseline. According to our results, the most important nodes were ?conceptual disorganization?, ?emotional withdrawal?, ?lack of spontaneity and flow of conversation?, ?delusions?, ?unusual thought content?, ?dealing with strangers? and ?poor rapport?. Our findings suggest that these symptoms and functioning dimensions should be prioritized in the clinical assessment and management of patients with FEP. These areas may also become targets of future early intervention strategies, so as to improve quality of life in this population.
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