Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 46, Issue 10, Pages 2444-2453Publisher
WILEY-BLACKWELL
DOI: 10.1002/eji.201646300
Keywords
Immunity; Mucosal-associated invariant T cell; Primary Sjogren syndrome
Categories
Funding
- Australian National Health and Medical Research Council (NHMRC) [1041900]
- NHMRC [1090759]
- National Health and Medical Research Council of Australia [1090759] Funding Source: NHMRC
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The frequencies, immunophenotype, and function of mucosal-associated invariant T (MAIT) cells were studied in patients with primary Sjogren syndrome (pSS) and healthy controls. MAIT cells were significantly decreased in the peripheral blood (PB) of patients with pSS. V alpha 7.2(+) MAIT cells were detected in the salivary gland tissue from pSS patients, but not in controls, indicating that the reduction ofMAIT cells in PB might be due to migration into the target tissue. Furthermore, the residual peripheral blood MAIT cells in pSS patients showed altered immunophenotype and function. While MAIT cells from controls were almost exclusively CD8(+) and expressed an effector memory immunophenotype, in pSS patients they were enriched in CD4(+) and naive subpopulations. Consistently, the functional studies demonstrated that MAIT cells from pSS showed a lower level of activation with reduced expression of CD69 and CD154 (CD40L), and a lower production of TNF and IFN-gamma. In summary, our findings demonstrate that MAIT cells were reduced and phenotypically and functionally altered in PB of pSS patients. The altered function of MAIT cells in target tissues from pSS patients may result in dysregulation of mucosal immunity leading to microbial damage of mucosal surfaces and subsequent initiation of autoimmune response.
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