Correlation of Coronary Artery Abnormalities with Fever Pattern in Patients with Kawasaki Disease

Objective To investigate the incidence of coronary artery abnormalities (CAAs) by fever pattern after intravenous immunoglobulin (IVIG) therapy in patients with Kawasaki disease. Study design This retrospective cohort study included 172 patients with Kawasaki disease aged <= 12 years who underwent IVIG therapy and had no CAAs before treatment. Resistance to initial IVIG was defined as persistent fever >= 37.5 degrees C for >= 24 hours after therapy or the recurrence of Kawasaki disease after initial defervescence. The patients were divided into 3 groups: IVIG responders, nonresponders with persistent fever, and nonresponders with recurrent fever. CAAs were evaluated 2 or 4 weeks and 12 months after onset and were defined by a coronary artery z-score >= 2.5. Results The incidence of CAAs within 12 months after onset was significantly higher in nonresponders with persistent fever (27%) compared with the other 2 groups. On multivariate logistic regression analysis, being a nonresponder with persistent fever was an independent risk factor for having CAAs within 12 months after the onset of Kawasaki disease (OR, 6.48; P =.007). Conclusions In patients with Kawasaki disease resistant to IVIG therapy, persistent fever, but not recurrent fever, was found to be a risk factor for the incidence of CAAs. Aggressive additional therapy may be beneficial to prevent CAA formation in patients with Kawasaki disease with persistent

Automated summary

In patients with Kawasaki disease resistant to IVIG therapy, persistent fever is found to be an independent risk factor for the incidence of coronary artery abnormalities (CAAs). Aggressive additional therapy may be beneficial to prevent CAAs formation in patients with Kawasaki disease with persistent fever.