4.7 Article

One-Pot Preparation of (E)-α,β-Unsaturated Aldehydes by a Julia-Kocienski Reaction of 2,2-Dimethoxyethyl PT Sulfone Followed by Acid Hydrolysis

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 9, Pages 6969-6973

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00479

Keywords

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Funding

  1. JSPS KAKENHI grant [17K05781]
  2. Grants-in-Aid for Scientific Research [17K05781] Funding Source: KAKEN

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(E)-alpha,beta-Unsaturated aldehydes were synthesized by the Julia-Kocienski reaction of 2,2-dimethoxyethyl 1-phenyl-1H-tetrazol-5-yl (PT) sulfone 3 with various aldehydes, followed by acid hydrolysis. The reaction could be carried out in one pot, and various (E)-alpha,beta-unsaturated aldehydes were obtained in a short time and with high yields.
(E)-alpha,beta-Unsaturated aldehydes were synthesized by the Julia-Kocienski reaction of 2,2-dimethoxyethyl 1-phenyl-1H-tetrazol-5-yl (PT) sulfone 3 with various aldehydes, followed by acid hydrolysis. The reaction could be carried out in one pot, and various (E)-alpha,beta-unsaturated aldehydes were obtained in a short time and with high yields.

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