4.7 Article

Direct Synthesis of N-Difluoromethyl-2-pyridones from Pyridines

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 9, Pages 6879-6887

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00228

Keywords

-

Funding

  1. Major National Science and Technology Projects of water pollution control and treatment [2017ZX07402003]
  2. Natural Science Foundation of Tianjin [19JCYBJC20200]
  3. Tianjin University

Ask authors/readers for more resources

A novel method for synthesizing N-difluoromethyl-2-pyridones from readily available pyridines has been described, utilizing mild reaction conditions and identifying N-difluoromethylpyridinium salts as key intermediates in the conversion process.
A novel method for the synthesis of N-difluoromethyl-2-pyridones was described. This protocol enables the synthesis of N-difluoromethyl-2-pyridones from readily available pyridines using mild reaction conditions that are compatible with a wide range of functional groups. The preliminary mechanistic study revealed that N-difluoromethylpyridinium salts were the key intermediates to complete this conversion.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available