Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 9, Pages 6879-6887Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00228
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Funding
- Major National Science and Technology Projects of water pollution control and treatment [2017ZX07402003]
- Natural Science Foundation of Tianjin [19JCYBJC20200]
- Tianjin University
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A novel method for synthesizing N-difluoromethyl-2-pyridones from readily available pyridines has been described, utilizing mild reaction conditions and identifying N-difluoromethylpyridinium salts as key intermediates in the conversion process.
A novel method for the synthesis of N-difluoromethyl-2-pyridones was described. This protocol enables the synthesis of N-difluoromethyl-2-pyridones from readily available pyridines using mild reaction conditions that are compatible with a wide range of functional groups. The preliminary mechanistic study revealed that N-difluoromethylpyridinium salts were the key intermediates to complete this conversion.
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