Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 9, Pages 6927-6930Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00324
Keywords
-
Categories
Funding
- Latvian Council of Science [lzp-2020/2-0045]
Ask authors/readers for more resources
The stereoselective total synthesis of a proposed potent serotonin 5-HT1A receptor agonist uncarialin A was achieved with a 17% overall yield using meroquinene tert-butyl ester as the chiral synthon. Spectral differences between the synthetic product and the sample isolated from natural sources suggest a need to revise the structure of the natural product.
The stereoselective total synthesis of the proposed structure of a potent serotonin 5-HT1A receptor agonist uncarialin A (1) is described. By employing the readily available meroquinene tert-butyl ester as the chiral synthon, the target structure has been prepared in a six-step linear sequence with a 17% overall yield. In comparison to the sample isolated from natural sources, the synthetic product shows significant spectral differences, strongly suggesting that the structure of the natural product should be revised.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available