Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 9, Pages 6755-6764Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00487
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Funding
- National Natural Science Foundation of China [21871087]
- Natural Science Foundation of Shandong Province [ZR2020QB013]
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An atom-economic procedure has been developed for the regioselective synthesis of bridged seven-membered-ring compounds from simple reactants. This process involves one-pot reactions of ring-expansion of indene-1,3-dione with alkynyl ketones and successive formal [4+2] cycloaddition, with the Michael addition reaction playing a key role in the regioselectivity of the formal [4+2] cycloaddition.
An atom economic procedure for the regioselective synthesis of bridged seven-membered-ring compounds from simple reactants such as ynones and indene-1,3-dione has been developed. This process was realized through the one-pot reactions of ring-expansion of indene-1,3-dione with alkynyl ketones and successive formal [4+2] cycloaddition. The Michael addition reaction is the key for the regioselectivity of the formal [4+2] cycloaddition.
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