Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 9, Pages 6622-6632Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00403
Keywords
-
Categories
Funding
- National Science Foundation of China [81573304, 81703342]
- Natural Science Foundation of Jiangsu [BK20161050]
- Natural Science Foundation of Nanjing University of Chinese Medicine [NZY81703342]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX19_1261]
Ask authors/readers for more resources
This reaction method is simple and efficient, allowing for the preparation of phenothiazine products from readily available starting materials, with high atom economy and broad substrate scope.
A one-pot and step economic reaction involving Rh(III)-catalyzed C-H thiolation and relay Cu(II)-catalyzed C-N amination of acetanilide and 2-bromothiophenol is reported here, with several valuable phenothiazine products obtained. This synthesis protocol proceeds from easily starting materials, demonstrating high atom economy, broad substrate scope, and good yield. Furthermore, the directing group can be easily eliminated, and chlorpromazine is provided in a large scale; thus this synthesis protocol could be utilized to construct phenothiazine scaffolds.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available