Correlation between Sarcopenia and Arteriosclerosis in Elderly Community Dwellers: A Multicenter Study

Background Evidence suggests that arteriosclerosis and sarcopenia (decreased muscle mass) share some of their many causes. However, after controlling for confounding factors, it is unclear whether the presence of arteriosclerosis correlates with sarcopenia. Objectives The aim of this paper is to explore whether sarcopenia is associated with arteriosclerosis. Design A multicenter cross-sectional community-based study. Materials and methods: A total of 2511 elderly subjects from six Chinese community health service centers in Anhui province were surveyed through an e-health promotion system to collect basic data and measurements of brachial-ankle pulse wave (baPWV), body composition, and handgrip strength (HGS). Pearson's correlation and binary logistic regression analyses were performed to identify associations between sarcopenia and high baPWV. Results The prevalence rates of sarcopenia were 12.9% in men and 15.3% in women according to the 2019 standard of Asian Working Group for Sarcopenia. Among subjects with high baPWV, the proportion of sarcopenia was higher compared to those with normal baPWV (men: 17.7% vs. 3.7%; women: 20.4% vs. 4.9%, both p<0.001). Binary logistic regression analysis revealed that sarcopenia was associated with high baPWV (p<0.0001, odds ratio=1.619) after adjusting for confounding factors. HGS slightly and negatively correlated with baPWV (-0.19 in men and -0.18 in women). Conclusions The intertwined pathophysiological mechanisms shared by arteriosclerosis and sarcopenia are potential targets for future interventions to reduce morbimortality in subjects with both disorders. Upcoming prospective studies and clinical trials are expected to advance these findings.

Automated summary

The study of 2511 elderly subjects found a positive correlation between sarcopenia and arteriosclerosis, with a higher prevalence of sarcopenia in subjects with high baPWV. Additionally, HGS was negatively correlated with baPWV. These findings suggest potential shared pathophysiological mechanisms between arteriosclerosis and sarcopenia, with implications for future interventions.