4.7 Article

Imaging Immunometabolism in Atherosclerosis

Journal

JOURNAL OF NUCLEAR MEDICINE
Volume 62, Issue 7, Pages 896-902

Publisher

SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.120.245407

Keywords

molecular imaging; atherosclerosis; immunometabolism; inflammation; macrophage; metabolic imaging

Funding

  1. NHLBI NIH HHS [K08 HL144911] Funding Source: Medline
  2. NIBIB NIH HHS [R21 EB027871] Funding Source: Medline

Ask authors/readers for more resources

In recent years, there has been an increasing recognition of the importance of immunometabolism in atherogenesis, particularly in understanding the role of immune cell activation and intracellular metabolism. Metabolic imaging, particularly with F-18-FDG, holds promise in providing valuable clinical insights for risk assessment and treatment monitoring in atherosclerosis patients.
Over the past decade, there has been a growing recognition of the links between intracellular metabolism and immune cell activation, that is, immunometabolism, and its consequences in atherogenesis. However, most immunometabolic investigations have been conducted in cultured cells through pharmacologic or genetic manipulations of selected immunologic or metabolic pathways, limiting their extrapolation to the complex microenvironment of plaques. In vivo metabolic imaging is ideally situated to address this gap and to determine the clinical implications of immunometabolic alterations for diagnosis and management of patients. Indeed, F-18-FDG has been widely used in clinical studies with promising results for risk stratification of atherosclerosis and monitoring the response to therapeutic interventions, though the biologic basis of its uptake in plaques has been evolving. Herein, we describe recent advances in understanding of immunometabolism of atherosclerosis with an emphasis on macrophages, and we review promising metabolic imaging approaches using F-18-FDG and other PET radiotracers.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available