Primary Neural Degeneration in Noise-Exposed Human Cochleas: Correlations with Outer Hair Cell Loss and Word-Discrimination Scores

Animal studies suggest that cochlear nerve degeneration precedes sensory cell degeneration in both noise-induced hearing loss (NIHL) and age-related hearing loss (ARHL), producing a hearing impairment that is not reflected in audiometric thresholds. Here, we investigated the histopathology of human ARHL and NIHL by comparing loss of auditory nerve fibers (ANFs), cochlear hair cells and the stria vascularis in a group of 52 cases with noise-exposure history against an age-matched control group. Although strial atrophy increased with age, there was no effect of noise history. Outer hair cell (OHC) loss also increased with age throughout the cochlea but was unaffected by noise history in the low-frequency region (>2 kHz), while greatly exacerbated at high frequencies (>= 2 kHz). Inner hair cell (IHC) loss was primarily seen at high frequencies but was unaffected by noise at either low or high frequencies. ANF loss was substantial at all cochlear frequencies and was exacerbated by noise throughout. According to a multivariable regression model, this loss of neural channels contributes to poor word discrimination among those with similar audiometric threshold losses. The histopathological patterns observed also suggest that, whereas the low-frequency OHC loss may be an unavoidable consequence of aging, the high-frequency loss, which produces the classic down-sloping audiogram of ARHL, may be partially because of avoidable ear abuse, even among those without a documented history of acoustic overexposure.

Automated summary

Animal studies indicate that cochlear nerve degeneration may precede sensory cell degeneration in both noise-induced and age-related hearing loss. Further investigation in human subjects shows that outer hair cell loss tends to increase with age throughout the cochlea, while inner hair cell loss is primarily seen at higher frequencies. Additionally, auditory nerve fiber loss is substantial at all frequencies and is exacerbated by noise exposure. The histopathological patterns suggest that the high-frequency hearing loss observed in age-related hearing loss may be partly avoidable due to ear abuse.