Synthesis, structural characterization and biological activities of transition metal complexes derived from 2,4-dihydroxybenzaldehyde n(4)-methyl(phenyl)thiosemicarbazone

A new thiosemicarbazone, (E)-2-(2,4-dihydroxybenzylidene)-N-methyl-N-phenylhydrazinecarbothioamide (L) was synthesized. Single crystals were grown by slow evaporation of its ethanolic solution at room temperature. The grown crystals were characterized by SCXRD, elemental analyses, FT-IR, 1H NMR and UV-Vis spectral analyses. Complexes of L with Co(II), Ni(II) and Cu(II) chlorides were synthesized and their structures were elucidated by elemental analyses, FT-IR, 1H NMR, UV-Vis, EPR spectral analyses and magnetic moment measurements. All these compounds were tested against microbial strains. The free-radical-scavenging ability of the ligand and the metal complexes was measured by their interaction with the stable DPPH free radical and all the compounds showed appreciable antioxidant activity. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

A new thiosemicarbazone and its metal complexes were synthesized and characterized, showing promising crystal growth and antioxidant activity.