4.7 Article

Structural Modeling of the SARS-CoV-2 Spike/Human ACE2 Complex Interface can Identify High-Affinity Variants Associated with Increased Transmissibility

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2

Amit Singh et al.

Summary: Studies on the structural mechanism of the novel coronavirus SARS-CoV-2 have identified the importance of amino acid residue S477 in the binding process with the hACE2 receptor, with its mutations S477G and S477N enhancing the binding of the spike protein to the receptor.

SCIENTIFIC REPORTS (2021)

Article Biology

The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types

Zharko Daniloski et al.

Summary: A novel variant of SARS-CoV-2 virus with mutation D614G has been found to be more effective at transducing human cells and showing increased infectivity in human cells compared to the wild-type variant.

ELIFE (2021)

Article Multidisciplinary Sciences

The SARS-CoV-2 Spike variant D614G favors an open conformational state

Rachael A. Mansbach et al.

Summary: The emergence of the G-form variant of COVID-19 has led to a more infectious strain with increased viral loads, likely due to changes in protein energetics favoring infection-capable states and enhanced exposure of the receptor binding domain. These findings are crucial for vaccine design.

SCIENCE ADVANCES (2021)

Article Biology

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2

Kushal Suryamohan et al.

Summary: This study analyzed genetic data and identified ACE2 variants that can potentially alter host susceptibility to SARS-CoV-2. Specific ACE2 variants were predicted to either increase susceptibility or provide protection against the virus by altering the interaction between the virus and host cells. Further biochemical assays confirmed the effects of these ACE2 variants on the affinity for the viral spike protein, suggesting that these genetic variations can modulate susceptibility to COVID-19.

COMMUNICATIONS BIOLOGY (2021)

Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

Article Multidisciplinary Sciences

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Renhong Yan et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Daniel Wrapp et al.

SCIENCE (2020)

Article Biochemistry & Molecular Biology

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

Qihui Wang et al.

Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

Article Multidisciplinary Sciences

Site-specific glycan analysis of the SARS-CoV-2 spike

Yasunori Watanabe et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Structural basis of receptor recognition by SARS-CoV-2

Jian Shang et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

ACE2gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population

Elisa Benetti et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2020)

Article Biochemistry & Molecular Biology

The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity

Qianqian Li et al.

Article Multidisciplinary Sciences

Convergent antibody responses to SARS-CoV-2 in convalescent individuals

Davide F. Robbiani et al.

NATURE (2020)

Article Multidisciplinary Sciences

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

Kui K. Chan et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

Lizhou Zhang et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

miR-122 and Ago interactions with the HCV genome alter the structure of the viral 5 terminus

Jasmin Chahal et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Pharmacology & Pharmacy

Receptor recognition and cross-species infections of SARS coronavirus

Fang Li

ANTIVIRAL RESEARCH (2013)

Article Biochemistry & Molecular Biology

Tertiary structure-based analysis of microRNA-target interactions

Hin Hark Gan et al.

Article Biochemistry & Molecular Biology

Mechanisms of Host Receptor Adaptation by Severe Acute Respiratory Syndrome Coronavirus

Kailang Wu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Review Microbiology

The spike protein of SARS-CoV - a target for vaccine and therapeutic development

Lanying Du et al.

NATURE REVIEWS MICROBIOLOGY (2009)

Article Biochemistry & Molecular Biology

Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2

WH Li et al.

EMBO JOURNAL (2005)