Journal
JOURNAL OF MEDICINAL FOOD
Volume 24, Issue 9, Pages 916-924Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2020.0073
Keywords
BDNF; cytokines; epilepsy; lithium– pilocarpine
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro-FAPERJ
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
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Research has shown that citral has inhibitory effects on status epilepticus in a rat model, increasing latency for seizure development, reducing neuronal death, and inhibiting overexpression of proinflammatory genes.
Epilepsy is one of the most common neurological disorders. About one-third of people with epilepsy are refractory to available treatments. Studies suggest that mechanisms linked to the immune response and inflammatory process are related to seizure disorders. Citral is a monoterpene found in the essential oil of several plants, as in Cymbopogon citratus, used to make teas and has been the subject of numerous researches, from which it has been possible to demonstrate antiseizure and anti-inflammatory activities. In this study, the effects of citral on status epilepticus (SE) induced by the lithium-pilocarpine model in rats were investigated. Quantitative reverse transcription PCR (RT-qPCR) evaluated latency for seizure development, neuronal death in the hippocampus, and expression of the brain-derived neurotrophic factor (BDNF), tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), interleukin-1 beta ( IL-1 beta) and factor nuclear kappa B (NF-kappa B) genes. The results revealed that citral was able to increase latency until the first seizure, decrease neuronal death 2 h after SE and inhibit overexpression of proinflammatory genes.
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