Related references
Note: Only part of the references are listed.The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models
Betty Y. Tam et al.
CANCER LETTERS (2020)
Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors
Benjamin N. Atkinson et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2020)
Untangling human neurogenesis to understand and counteract brain disorders
Ruth Beckervordersandforth et al.
CURRENT OPINION IN PHARMACOLOGY (2020)
Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
Youn-Sang Jung et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2020)
Antiepileptic Drug Carbamazepine Binds to a Novel Pocket on the Wnt Receptor Frizzled-8
Yuguang Zhao et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum
Yuguang Zhao et al.
JOURNAL OF PINEAL RESEARCH (2020)
Nature-derived compounds modulating Wnt/β-catenin pathway: a preventive and therapeutic opportunity in neoplastic diseases
Gianluca Sferrazza et al.
ACTA PHARMACEUTICA SINICA B (2020)
Wnts and the hallmarks of cancer
Zheng Zhong et al.
CANCER AND METASTASIS REVIEWS (2020)
Progenitors oppositely polarize WNT activators and inhibitors to orchestrate tissue development
Irina Matos et al.
ELIFE (2020)
Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity
William Mahy et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Single-Cell Profiling and SCOPE-Seq Reveal Lineage Dynamics of Adult Ventricular-Subventricular Zone Neurogenesis and NOTUM as a Key Regulator
Dogukan Mizrak et al.
CELL REPORTS (2020)
Caffeine inhibits Notum activity by binding at the catalytic pocket
Yuguang Zhao et al.
COMMUNICATIONS BIOLOGY (2020)
5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit
William Mahy et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Modulating Wnt signaling at the root: Porcupine and Wnt acylation
Viviana I. Torres et al.
PHARMACOLOGY & THERAPEUTICS (2019)
Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies
Swetha Raman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Crystal structure of a mammalian Wnt-frizzled complex
Hidenori Hirai et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)
Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans
Sofia Moverare-Skrtic et al.
FASEB JOURNAL (2019)
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium
Nalle Pentinmikko et al.
NATURE (2019)
EFFICACY AND SAFETY FROM A PHASE 2B TRIAL OF SM04690, A NOVEL, INTRA-ARTICULAR, WNT PATHWAY INHIBITOR FOR THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE
Y. Yazici et al.
OSTEOARTHRITIS AND CARTILAGE (2019)
Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment
V. Deshmukh et al.
OSTEOARTHRITIS AND CARTILAGE (2019)
An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent
Nicky J. Willis et al.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2019)
A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors
Malini Menon et al.
SCIENTIFIC REPORTS (2019)
NOTUM inhibition increases endocortical bone formation and bone strength
Robert Brommage et al.
BONE RESEARCH (2019)
Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen
Benjamin N. Atkinson et al.
MEDCHEMCOMM (2019)
Design and synthesis of gallocyanine inhibitors of DKK1/LRP6 interactions for treatment of Alzheimer's disease
Savvas Thysiadis et al.
BIOORGANIC CHEMISTRY (2018)
From instruction to output: Wnt/PCP signaling in development and cancer
Ashley Ceinwen Humphries et al.
CURRENT OPINION IN CELL BIOLOGY (2018)
A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee
V. Deshmukh et al.
OSTEOARTHRITIS AND CARTILAGE (2018)
Is beta-Catenin a Druggable Target for Cancer Therapy?
Can Cui et al.
TRENDS IN BIOCHEMICAL SCIENCES (2018)
Mechanisms of Wnt signaling and control
Stephanie Grainger et al.
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2018)
Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling
Radu M. Suciu et al.
ACS MEDICINAL CHEMISTRY LETTERS (2018)
Advanced Activity-Based Protein Profiling Application Strategies for Drug Development
Shan Wang et al.
FRONTIERS IN PHARMACOLOGY (2018)
Biomarker analyses from a phase I study of WNT974, a first-in-class Porcupine inhibitor, in patients (pts) with advanced solid tumors
Jordi Rodon et al.
CANCER RESEARCH (2018)
Crystal structure of the Frizzled 4 receptor in a ligand-free state
Shifan Yang et al.
NATURE (2018)
Discovery of Potent Disheveled/Dvl Inhibitors Using Virtual Screening Optimized With NMR-Based Docking Performance Index
Kiminori Hori et al.
FRONTIERS IN PHARMACOLOGY (2018)
Adult Hippocampal Neurogenesis: A Coming-of-Age Story
H. Georg Kuhn et al.
JOURNAL OF NEUROSCIENCE (2018)
Crystal structure of a membrane-bound O-acyltransferase
Dan Ma et al.
NATURE (2018)
Wnt is back in drugmakers' sights, but is it druggable?
Cormac Sheridan
NATURE BIOTECHNOLOGY (2018)
NOTUM Is Involved in the Progression of Colorectal Cancer
Jong Hyuk Yoon et al.
CANCER GENOMICS & PROTEOMICS (2018)
712 A small molecule modulator of the wnt pathway (SM04554) as a potential topical treatment for androgenetic alopecia (AGA)
V. Deshmukh et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)
Inhibition of β-Catenin Signaling in the Skin Rescues Cutaneous Adipogenesis in Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial of C-82
Robert Lafyatis et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2017)
Discovery of novel frizzled-7 inhibitors by targeting the receptor's transmembrane domain
Wei Zhang et al.
ONCOTARGET (2017)
Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl) ation and scaffolding
Laura Mariotti et al.
BRITISH JOURNAL OF PHARMACOLOGY (2017)
Rationale for targeting the Wnt signalling modulator Dickkopf-1 for oncology
Michael H. Kagey et al.
BRITISH JOURNAL OF PHARMACOLOGY (2017)
Abstract C45: Phase I study of WNT974, a first-in-class Porcupine inhibitor, in advanced solid tumors
Filip Janku et al.
MOLECULAR CANCER THERAPEUTICS (2016)
Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular-Subventricular Zone
Yuki Hirota et al.
NEUROCHEMICAL RESEARCH (2016)
Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase
James E. Tarver et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase
Qiang Han et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult Hippocampus
Aude Marzo et al.
CURRENT BIOLOGY (2016)
Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals
Kyle M. Loh et al.
DEVELOPMENTAL CELL (2016)
Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer's disease and related neurodegenerative tauopathies
Spyros Mpousis et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Fatty acylation of Wnt proteins
Aaron H. Nile et al.
NATURE CHEMICAL BIOLOGY (2016)
Dentin Dysplasia in Notum Knockout Mice
P. Vogel et al.
VETERINARY PATHOLOGY (2016)
NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition
Babita Madan et al.
ONCOTARGET (2016)
Wnt Drug Discovery: Weaving Through the Screens, Patents and Clinical Trials
Benjamin Lu et al.
CANCERS (2016)
Generation of Mice with Hepatocyte-Specific Conditional Deletion of Notum
Frederic Canal et al.
PLOS ONE (2016)
The use of porcupine inhibitors to target Wnt-driven cancers
Soo Yei Ho et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics
Shilong Zheng et al.
FUTURE MEDICINAL CHEMISTRY (2015)
Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled
Ho-Jin Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Notum deacylates Wnt proteins to suppress signalling activity
Satoshi Kakugawa et al.
NATURE (2015)
Novel insights into Notum and glypicans regulation in colorectal cancer
Mariangela De Robertis et al.
ONCOTARGET (2015)
Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice
Yosuke Osawa et al.
EBIOMEDICINE (2015)
Wnt pathway antagonist OMP-54F28 (FZD8-Fc) inhibits tumor growth and reduces tumor-initiating cell frequency in patient-derived hepatocellular carcinoma and ovarian cancer xenograft models
Pete Yeung et al.
CANCER RESEARCH (2014)
Identification of Key Residues and Regions Important for Porcupine-mediated Wnt Acylation
Jessica Rios-Esteves et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Can we safely target the WNT pathway?
Michael Kahn
NATURE REVIEWS DRUG DISCOVERY (2014)
An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
Hans Clevers et al.
SCIENCE (2014)
The Role of Ryk and Ror Receptor Tyrosine Kinases in Wnt Signal Transduction
Jennifer Green et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)
Drugging the undruggable: Transcription therapy for cancer
Chunhong Yan et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2013)
A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation-Driven Colorectal Tumor Growth
Ted Lau et al.
CANCER RESEARCH (2013)
Identification of NVP-TNKS656: The Use of Structure-Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor
Michael D. Shultz et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor
Andrew Voronkov et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Structure of the human smoothened receptor bound to an antitumour agent
Chong Wang et al.
NATURE (2013)
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
Jun Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Wnt Stabilization of β-Catenin Reveals Principles for Morphogen Receptor-Scaffold Assemblies
Sung-Eun Kim et al.
SCIENCE (2013)
Secreted and Transmembrane Wnt Inhibitors and Activators
Cristina-Maria Cruciat et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
Wnt/β-Catenin Signaling and Disease
Hans Clevers et al.
CELL (2012)
Roles of N-glycosylation and lipidation in Wg secretion and signaling
Xiaofang Tang et al.
DEVELOPMENTAL BIOLOGY (2012)
The pharmacological landscape and therapeutic potential of serine hydrolases
Daniel A. Bachovchin et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
Austin Gurney et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Structural Basis of Wnt Recognition by Frizzled
Claudia Y. Janda et al.
SCIENCE (2012)
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
Zhihong Cheng et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides: Part II
William J. Moore et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Structural Basis for the Interaction between Tankyrase-2 and a Potent Wnt-Signaling Inhibitor
Tobias Karlberg et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation
Peter V. N. Bodine et al.
BONE (2009)
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
Bryan T. MacDonald et al.
DEVELOPMENTAL CELL (2009)
Discovery and Characterization of a Small Molecule Inhibitor of the PDZ Domain of Dishevelled
David Grandy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: A Wingless β-Catenin Agonist That Increases Bone Formation Rate
Jeffrey C. Pelletier et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Modulation of Wnt Signaling Through Inhibition of Secreted Frizzled-Related Protein I (sFRP-1) with N-Substituted Piperidinyl Diphenylsulfonyl Sulfonamidest
William J. Moore et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
Shih-Min A. Huang et al.
NATURE (2009)
Inhibition of Wnt signaling by Dishevelled PDZ peptides
Yingnan Zhang et al.
NATURE CHEMICAL BIOLOGY (2009)
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
Baozhi Chen et al.
NATURE CHEMICAL BIOLOGY (2009)
Wingless Promotes Proliferative Growth in a Gradient-Independent Manner
Luis Alberto Baena-Lopez et al.
SCIENCE SIGNALING (2009)
Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF
Yuichi Torisu et al.
CANCER SCIENCE (2008)
Activation of Wingless Targets Requires Bipartite Recognition of DNA by TCF
Mikyung V. Chang et al.
CURRENT BIOLOGY (2008)
Monounsaturated fatty acid modification of Wnt protein: Its role in Wnt secretion
Ritsuko Takada et al.
DEVELOPMENTAL CELL (2006)
Dissecting nuclear Wingless signalling:: Recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins
R Städeli et al.
MECHANISMS OF DEVELOPMENT (2005)
WNT and β-catenin signalling:: Diseases and therapies
RT Moon et al.
NATURE REVIEWS GENETICS (2004)
A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription
KH Emami et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Opposing activities of dally-like glypican at high and low levels of wingless morphogen activity
J Kreuger et al.
DEVELOPMENTAL CELL (2004)
Wnt proteins are lipid-modified and can act as stem cell growth factors
K Willert et al.
NATURE (2003)
Wingful, an extracellular feedgack inhibitor of Wingless
O Gerlitz et al.
GENES & DEVELOPMENT (2002)
HSPG modification by the secreted enzyme notum shapes the wingless morphogen gradient
AJ Giráldez et al.
DEVELOPMENTAL CELL (2002)
Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains
CE Dann et al.
NATURE (2001)
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow
A Bafico et al.
NATURE CELL BIOLOGY (2001)
Crystal structure of a β-catenin/Tcf complex
TA Graham et al.
CELL (2000)
Share Paper
