Journal
JOURNAL OF MEDICAL VIROLOGY
Volume 93, Issue 9, Pages 5608-5613Publisher
WILEY
DOI: 10.1002/jmv.27037
Keywords
adaptive immunity; COVID-19; SARS-CoV-2; T lymphocytes
Categories
Funding
- Mediolanum Farmaceutici S.p.A.
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In severe COVID-19 patients, the expansion of circulating T cells may induce antibody response, inflammation, and regulation, potentially leading to a new form of biological target therapy.
In this observational study, 13 patients with severe COVID-19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID-19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible new form of biological target therapy.
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