Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 110, Issue 3, Pages 525-537Publisher
WILEY
DOI: 10.1002/JLB.3MR0321-755R
Keywords
bone metabolism; gut microbiota; osteoimmunology; osteoporosis; probiotics
Categories
Funding
- National Natural Science Foundation of China [81800989, 81870754, 81771099]
Ask authors/readers for more resources
The gut microbiota plays a crucial role in skeletal health by influencing host metabolism, immune function, and hormonal secretion. Novel gut microbiota-targeting therapeutics, such as probiotics and prebiotics, have shown effectiveness in preventing bone loss.
The gastrointestinal tract is colonized by trillions of microorganisms, consisting of bacteria, fungi, and viruses, known as the second gene pool of the human body. In recent years, the microbiota-gut-bone axis has attracted increasing attention in the field of skeletal health/disorders. The involvement of gut microbial dysbiosis in multiple bone disorders has been recognized. The gut microbiota regulates skeletal homeostasis through its effects on host metabolism, immune function, and hormonal secretion. Owing to the essential role of the gut microbiota in skeletal homeostasis, novel gut microbiota-targeting therapeutics, such as probiotics and prebiotics, have been proven effective in preventing bone loss. However, more well-controlled clinical trials are still needed to evaluate the long-term efficacy and safety of these ecologic modulators in the treatment of bone disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available