4.7 Article

Meeting Report: Psoriasis Stratification to Optimize Relevant Therapy Showcase

Journal

JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 141, Issue 8, Pages 1872-1878

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2021.02.746

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Funding

  1. Medical Research Council Stratified Medicine award [MR/L011808/1]
  2. Psoriasis Association
  3. British Association of Dermatologists
  4. AbbVie
  5. Becton Dickinson and Company
  6. Celgene
  7. Eli Lilly and Company
  8. GlaxoSmithKline
  9. Janssen Research & Development LLC
  10. LEO Pharma
  11. Medimmune
  12. Novartis Pharmaceuticals UK
  13. Pfizer
  14. National Institute for Health Research (NIHR) Biomedical Research Centres at King's College London
  15. Guy and St Thomas NHS Foundation Trust, Manchester
  16. Guy and St Thomas NHS Foundation Trust, Newcastle
  17. NIHR Newcastle Biomedical Research Centre

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A stratified medicine approach for psoriasis treatment aims to improve clinical decision-making by predicting individual patient response based on clinical, pharmacological, and omics data. The PSORT Consortium, funded by the UK Medical Research Council, focuses on discovering predictors and stratifiers of psoriasis response to biologic therapies. A showcase meeting in London in November 2019 highlighted the research findings and significant advances made by PSORT towards personalized management of psoriasis.
A stratified medicine approach for the treatment of psoriasis promises greater certainty of clinical decision making through prediction of response on the basis of clinical, pharmacological, and omics data from an individual patient. As yet, there is no predictive model for treatment response in routine clinical use for psoriasis. The Psoriasis Stratification to Optimise Relevant Therapy (PSORT) Consortium is a United Kingdom Medical Research Council.funded, academic.industrial stratified medicine consortium established with the objective of discovering the predictors and stratifiers of response of psoriasis to biologic therapies. A showcase meeting was convened and attended by 80 stakeholders at the Royal College of Physicians, London, United Kingdom on 18 November 2019. The purpose was to disseminate the research findings from the PSORT consortium discovered thus far. This report summarizes the presentations made on the day and the significant advances made by PSORT toward a stratified medicine approach to the management of psoriasis.

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