Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 218, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2021.111387
Keywords
Curcumin; Bisdemethoxycurcumin; Ruthenium complexes; 1; 4; 7-trithiacyclononane; Anticancer activity; Metal complexes interaction with protein; lysozyme
Funding
- University of Camerino
- Ente Cassa Risparmio Firenze (ECR)
- AIRC [19650]
- Beneficentia Stiftung, Vaduz
- University of Pisa [PRA_2020_58]
- University of Pisa
Ask authors/readers for more resources
This study investigated the interactions between two cationic ruthenium(II) [9]aneS3 complexes and a model protein, revealing a limited reactivity and modest cytotoxicity against cancer cell lines. The moderate pharmacological activity is likely attributed to the relatively high stability of these complexes.
Two cationic ruthenium(II) 1,4,7-trithiacyclononane ([9]aneS3) complexes of curcumin (curcH) and bisdemethoxycurcumin (bdcurcH), namely [Ru(curc)(dmso-S)([9]aneS3)]Cl (1) and [Ru(bdcurc)(dmso-S)([9]aneS3)]Cl (2) were prepared from the [RuCl2(dmso-S)([9]-aneS3)] precursor and structurally characterized, both in solution and in the solid state by X-ray crystallography. The corresponding PTA complexes [Ru(curc)(PTA)([9] aneS3)]Cl (3) and [Ru(bdcurc)(PTA)([9]aneS3)]Cl (4) have been also synthesized and characterized (PTA = 1,3,5-triaza-7-phosphaadamantane). Bioinorganic studies relying on mass spectrometry were performed on complexes 1?4 to assess their interactions with the model protein lysozyme. Overall, a rather limited reactivity with lysozyme was highlighted accompanied by a modest cytotoxic potency against three representative cancer cell lines. The moderate pharmacological activity is likely connected to the relatively high stability of these complexes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available