Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 225, Issue 10, Pages 1807-1810Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiab209
Keywords
Pneumocystis jirovecii; preterm infants; vertical transmission; respiratory distress syndrome; bronchopulmonary dysplasia
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Funding
- Polish Ministry of Health from the IT Simple system of Wroclaw Medical University [STM.A060.20.093, STM.A060.20.105, SUB.A300.19.015]
- University of Chile [ENL30/19]
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The study revealed the prevalence of Pneumocystis jirovecii in mother-infant pairs of very low birth weight newborns, with Pneumocystis DNA detected in both newborns and mothers. The finding of Pneumocystis detection immediately after birth suggests the possibility of its transplacental transmission, and colonized infants were more likely to develop bronchopulmonary dysplasia, indicating a potential clinical importance of this pathogen in abnormal lung development.
We describe the prevalence of Pneumocystis jirovecii in mother-infant pairs of very low birth weight newborns P. jirovecii in patients' specimens. Pneumocystis DNA was detected in 8 nasopharyngeal aspirates (14%) of 56 newborns and in 7 oral washes (21%) of 34 mothers. Pneumocystis detection immediately after birth suggests the possibility of its transplacental transmission. Compared to noncolonized infants, more frequent occurrence of bronchopulmonary dysplasia was seen in colonized infants (P = .02), suggesting a potential clinical importance of this pathogen in abnormal lung development.
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