The Mononuclear Phagocyte System of the Rat

The laboratory rat continues to be the model of choice for many studies of physiology, behavior, and complex human diseases. Cells of the mononuclear phagocyte system (MPS; monocytes, macrophages, and dendritic cells) are abundant residents in every tissue in the body and regulate postnatal development, homeostasis, and innate and acquired immunity. Recruitment and proliferation of MPS cells is an essential component of both initiation and resolution of inflammation. The large majority of current knowledge of MPS biology is derived from studies of inbred mice, but advances in technology and resources have eliminated many of the advantages of the mouse as a model. In this article, we review the tools available and the current state of knowledge of development, homeostasis, regulation, and diversity within the MPS of the rat.

Automated summary

The laboratory rat remains a preferred model for studies in physiology, behavior, and complex human diseases, with the mononuclear phagocyte system playing a crucial role in regulating various bodily functions. Recruitment and proliferation of MPS cells are essential in the initiation and resolution of inflammation. Despite most knowledge in MPS biology originating from studies of inbred mice, advances in technology have made the rat model increasingly valuable.