Catalyst-free synthesis of quinazolinones by oxidative cyclization under visible light in the absence of additives

A general metal-free oxidative cyclization route was developed to synthesize quinazolinones under visible light. A series of substituted 2-aminobenzamides were reacted with aldehydes or ketones to produce the desired quinazolinones in good yields. Most importantly, the reaction did not require excess oxidant or high temperatures.

Automated summary

A general metal-free oxidative cyclization route has been developed for the synthesis of quinazolinones under visible light. Substituted 2-aminobenzamides reacted with aldehydes or ketones to yield the desired products in good yields without the requirement of excess oxidant or high temperatures.