Related references
Note: Only part of the references are listed.Proton pump inhibitors selectively suppress MLL rearranged leukemia cells via disrupting MLL1-WDR5 protein-protein interaction
Wei-Lin Chen et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia
Szymon Klossowski et al.
JOURNAL OF CLINICAL INVESTIGATION (2020)
Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target
Krzysztof Brzezinka et al.
CANCERS (2020)
Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription
Dan Tang et al.
CELL DISCOVERY (2020)
Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with Strong In Vivo Antitumor Activity
Shilin Xu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Evaluation of VTP-50469, a menin-MLL1 inhibitor, against Ewing sarcoma xenograft models by the pediatric preclinical testing consortium
Raushan T. Kurmasheva et al.
PEDIATRIC BLOOD & CANCER (2020)
Covalent and noncovalent constraints yield a figure eight-like conformation of a peptide inhibiting the menin-MLL interaction
Paulina Fortuna et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha
Yujing Gao et al.
COMMUNICATIONS BIOLOGY (2020)
BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity
Charles R. Schmidt et al.
BLOOD CANCER DISCOVERY (2020)
Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity
Erin R. Aho et al.
CELL REPORTS (2019)
Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization
Ying Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia
Krzysztof Brzezinka et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)
Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction
Angelo Aguilar et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Rewiring the Epigenetic Networks in MLL-Rearranged Leukemias: Epigenetic Dysregulation and Pharmacological Interventions
Anthony K. N. Chan et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)
Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition
Alan N. Engelman
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1
Xiaomin Ni et al.
ACS MEDICINAL CHEMISTRY LETTERS (2019)
Co-inhibition of HDAC and MLL-menin interaction targets MLL-rearranged acute myeloid leukemia cells via disruption of DNA damage checkpoint and DNA repair
Jing Ye et al.
CLINICAL EPIGENETICS (2019)
The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening
Xiaoqing Ye et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)
A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia
Andrei V. Krivtsov et al.
CANCER CELL (2019)
Discovery of a Selective Inhibitor for the YEATS Domains of ENL/AF9
Thomas Christott et al.
SLAS DISCOVERY (2019)
Targeting WDR5: A WINning Anti-Cancer Strategy?
Erin R. Aho et al.
EPIGENETICS INSIGHTS (2019)
Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction
Shilin Xu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)
Design, synthesis, and initial evaluation of affinity-based small molecular probe for detection of WDR5
Wei-Lin Chen et al.
BIOORGANIC CHEMISTRY (2018)
Piribedil disrupts the MLL1-WDR5 interaction and sensitizes MLL-rearranged acute myeloid leukemia (AML) to doxorubicin-induced apoptosis
Xiong Zhang et al.
CANCER LETTERS (2018)
Complexity of Blocking Bivalent Protein Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction
Dmitry Borkin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Discovery of Potent 2-Aryl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design
Feng Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Born to run: control of transcription elongation by RNA polymerase II
Fei Xavier Chen et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation
Subhalakshmi Sharma et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Peptidomimetics for Targeting Protein-Protein Interactions between DOT1 L and MLL Oncofusion Proteins AF9 and ENL
Lei Du et al.
ACS MEDICINAL CHEMISTRY LETTERS (2018)
Discovery of an MLLT1/3 YEATS Domain Chemical Probe
Moses Moustakim et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)
Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy
Kaiwei Liang et al.
CELL (2018)
Structure-guided development of YEATS domain inhibitors by targeting pi-pi-pi stacking
Xin Li et al.
NATURE CHEMICAL BIOLOGY (2018)
Direct Binding of BCOR, but Not CBX8, to MLL-AF9 Is Essential for MLL-AF9 Leukemia Via Regulation of the EYA1/SIX1 Gene Network
John H. Bushweller et al.
BLOOD (2018)
A novel small molecule menin-MLL inhibitor for potential treatment of MLL-rearranged leukemias and NPM1/DNMT3A-mutant AML
Francis Burrows et al.
MOLECULAR CANCER THERAPEUTICS (2018)
Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia
C. Dafflon et al.
LEUKEMIA (2017)
Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction
Hacer Karatas et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Targeting Unoccupied Surfaces on Protein-Protein Interfaces
David Rooklin et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Transcription control by the ENL YEATS domain in acute leukaemia
Michael A. Erb et al.
NATURE (2017)
ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia
Liling Wan et al.
NATURE (2017)
Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription
Shiqian Qi et al.
NATURE COMMUNICATIONS (2017)
Role of Host Factors on the Regulation of Tat-Mediated HIV-1 Transcription
Guillaume Mousseau et al.
CURRENT PHARMACEUTICAL DESIGN (2017)
MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia
Yufei Chen et al.
CANCER CELL (2017)
Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia
Kaiwei Liang et al.
CELL (2017)
Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner
S. He et al.
LEUKEMIA (2016)
Enhancer deregulation in cancer and other diseases
Hans-Martin Herz
BIOESSAYS (2016)
Structure-based design of ester compounds to inhibit MLL complex catalytic activity by targeting mixed lineage leukemia 1 (MLL1)-WDR5 interaction
Dong-Dong Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2016)
Design and synthesis of benzylpiperidine inhibitors targeting the menin-MLL1 interface
Jing Ren et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction
Hai-Jing Zhong et al.
CHEMICAL COMMUNICATIONS (2016)
Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5
Dong-Dong Li et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity
Dong-Dong Li et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300
H. Jane Dyson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes
Nilda L. Alicea-Velazquez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Discovery of Novel Inhibitors Targeting the Menin-Mixed Lineage Leukemia Interface Using Pharmacophore- and Docking-Based Virtual Screening
Yuan Xu et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2016)
Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)
Dmitry Borkin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1)
Matthaeus Getlik et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain
Yuanyuan Li et al.
MOLECULAR CELL (2016)
Structural basis for activity regulation of MLL family methyltransferases
Yanjing Li et al.
NATURE (2016)
The molecular mechanics of mixed lineage leukemia
R. K. Slany
ONCOGENE (2016)
Identification of novel small-molecule inhibitors targeting menin-MLL interaction, repurposing the antidiarrheal loperamide
Liyan Yue et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2016)
MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program
Jing Xu et al.
CELL DISCOVERY (2016)
Progress towards small molecule menin-mixed lineage leukemia (MLL) interaction inhibitors with in vivo utility
Timothy Senter et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo
Dmitry Borkin et al.
CANCER CELL (2015)
A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation
Pamela Zhang et al.
GENES & DEVELOPMENT (2015)
Pharmacological targeting of the Wdr5-MLL interaction in C/EBP alpha N-terminal leukemia
Florian Grebien et al.
NATURE CHEMICAL BIOLOGY (2015)
Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription
Huasong Lu et al.
NUCLEIC ACIDS RESEARCH (2015)
Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif
Petr Tesina et al.
NATURE COMMUNICATIONS (2015)
Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential
Aravinda Kuntimaddi et al.
CELL REPORTS (2015)
Hijacked in cancer: the KMT2 (MLL) family of methyltransferases
Rajesh C. Rao et al.
NATURE REVIEWS CANCER (2015)
Diverse functions of PHD fingers of the MLL/KMT2 subfamily
Muzaffar Ali et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2014)
Discovery of two aminoglycoside antibiotics as inhibitors targeting the menin-mixed lineage leukaemia interface
Lianchun Li et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Validation and Structural Characterization of the LEDGF/p75-MLL Interface as a New Target for the Treatment of MLL-Dependent Leukemia
Katerina Cermakova et al.
CANCER RESEARCH (2014)
AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation
Yuanyuan Li et al.
CELL (2014)
Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4
Jianyou Gu et al.
CELL CYCLE (2014)
High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein-Protein Interaction
Shihan He et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia
Fang Cao et al.
MOLECULAR CELL (2014)
Molecular recognition by the KIX domain and its role in gene regulation
Jitendra K. Thakur et al.
NUCLEIC ACIDS RESEARCH (2014)
The mechanism of binding of the KIX domain to the mixed lineage leukemia protein and its allosteric role in the recognition of c-Myb
Angelo Toto et al.
PROTEIN SCIENCE (2014)
The Histone Methyltransferase Activity of MLL1 Is Dispensable for Hematopoiesis and Leukemogenesis
Bibhu P. Mishra et al.
CELL REPORTS (2014)
AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter
Ursula Schulze-Gahmen et al.
ELIFE (2014)
Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5
Guillermo Senisterra et al.
BIOCHEMICAL JOURNAL (2013)
Bromo-deaza-SAH: A potent and selective DOT1L inhibitor
Wenyu Yu et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
Scott R. Daigle et al.
BLOOD (2013)
Targeting Recruitment of Disruptor of Telomeric Silencing 1-like (DOT1L) CHARACTERIZING THE INTERACTIONS BETWEEN DOT1L AND MIXED LINEAGE LEUKEMIA (MLL) FUSION PROTEINS
Chenxi Shen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Structure-Based Design of High-Affinity Macrocyclic Peptidomimetics to Block the Menin-Mixed Lineage Leukemia 1 (MLL1) Protein-Protein Interaction
Haibin Zhou et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein-Protein Interaction
Hacer Karatas et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75)
H. Mereau et al.
LEUKEMIA (2013)
Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes
Jocelyn O. Eidahl et al.
NUCLEIC ACIDS RESEARCH (2013)
HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold
Seemay Chou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Leukemia Fusion Target AF9 Is an Intrinsically Disordered Transcriptional Regulator that Recruits Multiple Partners via Coupled Folding and Binding
Benjamin I. Leach et al.
STRUCTURE (2013)
Menin: a scaffold protein that controls gene expression and cell signaling
Smita Matkar et al.
TRENDS IN BIOCHEMICAL SCIENCES (2013)
Synthesis, activity and metabolic stability of non-ribose containing inhibitors of histone methyltransferase DOT1L
Lisheng Deng et al.
MEDCHEMCOMM (2013)
Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction
Yuri Bolshan et al.
ACS MEDICINAL CHEMISTRY LETTERS (2013)
MLL-ENL Inhibits Polycomb Repressive Complex 1 to Achieve Efficient Transformation of Hematopoietic Cells
Emanuel Maethner et al.
CELL REPORTS (2013)
The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat
Ursula Schulze-Gahmen et al.
ELIFE (2013)
Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
Panagis Filippakopoulos et al.
CELL (2012)
Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30
Yong Chen et al.
CELL RESEARCH (2012)
Conformational Adaptation Drives Potent, Selective and Durable Inhibition of the Human Protein Methyltransferase DOT1L
Aravind Basavapathruni et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2012)
A Subset of Mixed Lineage Leukemia Proteins Has Plant Homeodomain (PHD)-mediated E3 Ligase Activity
Jingya Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Structural Basis for WDR5 Interaction (Win) Motif Recognition in Human SET1 Family Histone Methyltransferases
Venkatasubramanian Dharmarajan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Synthesis and Structure-Activity Relationship Investigation of Adenosine-Containing Inhibitors of Histone Methyltransferase DOT1L
Justin L. Anglin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Phage Display-directed Discovery of LEDGF/p75 Binding Cyclic Peptide Inhibitors of HIV Replication
Belete A. Desimmie et al.
MOLECULAR THERAPY (2012)
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription
Jing Huang et al.
NATURE (2012)
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
Jolanta Grembecka et al.
NATURE CHEMICAL BIOLOGY (2012)
The super elongation complex (SEC) family in transcriptional control
Zhuojuan Luo et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
Wenyu Yu et al.
NATURE COMMUNICATIONS (2012)
ELL facilitates RNA polymerase II pause site entry and release
Jung S. Byun et al.
NATURE COMMUNICATIONS (2012)
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome
Qian-fei Wang et al.
BLOOD (2011)
Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
Scott R. Daigle et al.
CANCER CELL (2011)
CBX8, a Polycomb Group Protein, Is Essential for MLL-AF9-Induced Leukemogenesis
Jiaying Tan et al.
CANCER CELL (2011)
Fine-tuning the stimulation of MLL1 methyltransferase activity by a histone H3-based peptide mimetic
Vanja Avdic et al.
FASEB JOURNAL (2011)
被撤回的出版物: Role of the PWWP Domain of Lens Epithelium-derived Growth Factor (LEDGF)/p75 Cofactor in Lentiviral Integration Targeting (Retracted article. See vol. 293, pg. 114, 2018)
Rik Gijsbers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways
Akihiko Yokoyama et al.
JOURNAL OF CELL SCIENCE (2011)
New Insights into the Control of HIV-1 Transcription: When Tat Meets the 7SK snRNP and Super Elongation Complex (SEC)
Nanhai He et al.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2011)
Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies
Yuan Yao et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
The heterodimerization domains of MLL-FYRN and FYRC-are potential target structures in t(4;11) leukemia
B. Pless et al.
LEUKEMIA (2011)
Structural and Biochemical Insights into MLL1 Core Complex Assembly
Vanja Avdic et al.
STRUCTURE (2011)
The PHD3 Domain of MLL Acts as a CYP33-Regulated Switch between MLL-Mediated Activation and Repression
Sangho Park et al.
BIOCHEMISTRY (2010)
A Higher-Order Complex Containing AF4 and ENL Family Proteins with P-TEFb Facilitates Oncogenic and Physiologic MLL-Dependent Transcription
Akihiko Yokoyama et al.
CANCER CELL (2010)
MLL-AF9-Induced Leukemogenesis Requires Coexpression of the Wild-Type Mll Allele
Austin T. Thiel et al.
CANCER CELL (2010)
The PAF Complex Synergizes with MLL Fusion Proteins at HOX Loci to Promote Leukemogenesis
Andrew G. Muntean et al.
CANCER CELL (2010)
Pro Isomerization in MLL1 PHD3-Bromo Cassette Connects H3K4me Readout to CyP33 and HDAC-Mediated Repression
Zhanxin Wang et al.
CELL (2010)
Epigenome Mapping in Normal and Disease States
Alika K. Maunakea et al.
CIRCULATION RESEARCH (2010)
Mixed lineage leukemia: a structure-function perspective of the MLL1 protein
Michael S. Cosgrove et al.
FEBS JOURNAL (2010)
Leu628 of the KIX domain of CBP is a key residue for the interaction with the MLL transactivation domain
Munehito Arai et al.
FEBS LETTERS (2010)
Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)
Man Mohan et al.
GENES & DEVELOPMENT (2010)
Molecular Basis of the Mixed Lineage Leukemia-Menin Interaction IMPLICATIONS FOR TARGETING MIXED LINEAGE LEUKEMIAS
Jolanta Grembecka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Analysis of the Binding of Mixed Lineage Leukemia 1 (MLL1) and Histone 3 Peptides to WD Repeat Domain 5 (WDR5) for the Design of Inhibitors of the MLL1-WDR5 Interaction
Hacer Karatas et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Binding of the MLL PHD3 Finger to Histone H3K4me3 Is Required for MLL-Dependent Gene Transcription
Pei-Yun Chang et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis
Thomas A. Milne et al.
MOLECULAR CELL (2010)
HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription
Nanhai He et al.
MOLECULAR CELL (2010)
AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia
Chengqi Lin et al.
MOLECULAR CELL (2010)
HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP
Bijan Sobhian et al.
MOLECULAR CELL (2010)
Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis
T. Gan et al.
LEUKEMIA (2010)
LEDGF Hybrids Efficiently Retarget Lentiviral Integration Into Heterochromatin
Rik Gijsbers et al.
MOLECULAR THERAPY (2010)
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication
Frauke Christ et al.
NATURE CHEMICAL BIOLOGY (2010)
The structure of the FYR domain of transforming growth factor beta regulator 1
Maria M. Garcia-Alai et al.
PROTEIN SCIENCE (2010)
Amphipathic Small Molecules Mimic the Binding Mode and Function of Endogenous Transcription Factors
Sara J. Buhrlage et al.
ACS CHEMICAL BIOLOGY (2009)
MLL histone methylases in gene expression, hormone signaling and cell cycle
Khairul I. Ansari et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2009)
Lens Epithelium-derived Growth Factor/p75 Interacts with the Transposase-derived DDE Domain of PogZ
Koen Bartholomeeusen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Direct Observation of the Dynamic Process Underlying Allosteric Signal Transmission
Sven Brueschweiler et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Structural Basis for the Requirement of Additional Factors for MLL1 SET Domain Activity and Recognition of Epigenetic Marks
Stacey M. Southall et al.
MOLECULAR CELL (2009)
LEDGF/p75 Proteins with Alternative Chromatin Tethers Are Functional HIV-1 Cofactors
Anne M. Meehan et al.
PLOS PATHOGENS (2009)
Menin critically links MLL proteins with LEDGE on cancer-associated target genes
Akihiko Yokoyama et al.
CANCER CELL (2008)
H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias
Andrei V. Krivtsov et al.
CANCER CELL (2008)
Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization
Jing Chen et al.
CANCER RESEARCH (2008)
Structure of WDR5 Bound to Mixed Lineage Leukemia Protein-1 Peptide
Anamika Patel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
WDR5 Interacts with Mixed Lineage Leukemia (MLL) Protein via the Histone H3-binding Pocket
Ji-Joon Song et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
A Conserved Arginine-containing Motif Crucial for the Assembly and Enzymatic Activity of the Mixed Lineage Leukemia Protein-1 Core Complex
Anamika Patel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells
Christine M. Palermo et al.
LEUKEMIA RESEARCH (2008)
Outcome of risk-based therapy for infant acute lymphoblastic leukemia with or without an MLL gene rearrangement, with emphasis on late effects: A final report of two consecutive studies, MLL96 and MLL98, of the Japan Infant Leukemia Study Group
D. Tomizawa et al.
LEUKEMIA (2007)
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
Sean D. Taverna et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
MLL translocations, histone modifications and leukaemia stem-cell development
Andrei V. Krivtsov et al.
NATURE REVIEWS CANCER (2007)
MII has a critical role in fetal and adult hematopoietic stem cell self-renewal
Kathryn A. McMahon et al.
CELL STEM CELL (2007)
Interaction of MLL amino terminal sequences with menin is required for transformation
Corrado Caslini et al.
CANCER RESEARCH (2007)
Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36
Xiaobing Shi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication
Jan De Rijck et al.
JOURNAL OF VIROLOGY (2006)
Menin and its interacting proteins:: elucidation of menin function
Katalin Balogh et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2006)
Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations
Heidi G. Sutherland et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Regulation of MLL1 H3K4 methyltransferase activity by its core components
Yali Dou et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75
Manuel Llano et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Analysis of prognostic factors of acute lymphoblastic leukemia in infants: report on CCG 1953 from the Children's Oncology Group
Joanne M. Hilden et al.
BLOOD (2006)
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF
Haitao Li et al.
NATURE (2006)
Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2
Pedro V. Pena et al.
NATURE (2006)
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling
Joanna Wysocka et al.
NATURE (2006)
Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll
R Terranova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Structural basis for cooperative transcription factor binding to the CBP coactivator
RN De Guzman et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression
YX Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis
A Yokoyama et al.
CELL (2005)
Physical association and coordinate function of the H3K4 methyltransferase MLL1 and the H4K16 acetyltransferase MOF
YL Dou et al.
CELL (2005)
WDR5 associates with histone H3 methylated at K4 and is essential for H3K4 methylation and vertebrate development
J Wysocka et al.
CELL (2005)
Global and Hox-specific roles for the MLL1 methyltransferase
MG Guenther et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis
A Daser et al.
SEMINARS IN CANCER BIOLOGY (2005)
Hox regulation of normal and leukemic hematopoietic stem cells
Carolina Abramovich et al.
CURRENT OPINION IN HEMATOLOGY (2005)
hDOT1L links histone methylation to leukemogenesis
Y Okada et al.
CELL (2005)
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors
TA Milne et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Menin associates with a trithorax family histone methyltransferase complex and with the Hoxc8 locus
CM Hughes et al.
MOLECULAR CELL (2004)
CBP and p300: HATs for different occasions
E Kalkhoven
BIOCHEMICAL PHARMACOLOGY (2004)
The synthetic peptide PFWT disrupts AF4-AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells
RS Srinivasan et al.
LEUKEMIA (2004)
Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression
A Yokoyama et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Gene expression profiling of pediatric acute myelogenous leukemia
ME Ross et al.
BLOOD (2004)
MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein
ZB Xia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor
RS Srinivasan et al.
ONCOGENE (2003)
Genetic ablation of the tumor suppresor menin causes lethality at mid-gestation with defects in multiple organs
P Bertolino et al.
MECHANISMS OF DEVELOPMENT (2003)
Menin interacting proteins as clues toward the understanding of multiple endocrine neoplasia type 1
A Poisson et al.
CANCER LETTERS (2003)
Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization
JJD Hsieh et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP) - The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain
NK Goto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain
Q Feng et al.
CURRENT BIOLOGY (2002)
Large-scale identification of mammalian proteins localized to nuclear sub-compartments
HGE Sutherland et al.
HUMAN MOLECULAR GENETICS (2001)
Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo
SH Chao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells
K Fair et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
MLL amplification in acute leukaemia:: a United Kingdom Cancer Cytogenetics Group (UKCCG) study
G Cuthbert et al.
LEUKEMIA (2000)
Flavopiridol inhibits P-TEFb and blocks HIV-1 replication
SH Chao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)