Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 409, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jhazmat.2020.124531
Keywords
Indoor/outdoor air; Indoor dust; PAHs; Health risk; Children
Categories
Funding
- Singapore Ministry of Education Academic Research Fund Tier 1 [04MNP000567C120, M4082370.030]
- National Environment Agency - Singapore [04SBS000714N025]
- Singapore Ministry of Health's National Medical Research Council under its Clinician-Scientist Individual Research Grant (CS-IRG) [MOH-000141, OFIRG/0076/2018]
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The study found that while the total concentration of PAHs in indoor air has decreased, it remains steady in outdoor air and indoor dust. Additionally, more carcinogenic PAHs were observed in indoor/outdoor air in Asia, while in dust samples this was more prevalent in North America. Monte-Carlo simulations showed that children's exposure to indoor sources in dust and air exceeded outdoor levels.
Polycyclic aromatic hydrocarbons (PAHs) are among the most health-relevant air pollutants. Herein, we conducted meta-analysis and experimental validation to evaluate PAHs in our surroundings and carcinogenic risks. We summarized the occurrence of PAHs in outdoors and indoors from 131 studies with 6,766 samples collected in different countries in 1989-2019. The global weighted-median concentration in outdoor air, indoor air and dust of Sigma PAHs were 142 ng/m(3), 369 ng/m(3) and 10,201 ng/g; respectively. Sigma PAHs have decreased in indoor air but remained steady in outdoor air and indoor dust. More carcinogenic PAHs in indoor/outdoor air was observed in Asia, while in dust was North America. Monte-Carlo simulation further showed indoor sources for children's exposure from dust and air can exceed outdoor. To further validate the health effect of PAHs from indoors, 15 more recent indoor dust samples were collected to examine their mutagenicity. The results showed that Sigma PAHs were found to be significantly correlated with mutagenicity potency in the dust sample metabolically activated with liver S9 subcellular fraction and likely accounted for 0.42-0.50 of the mutagenic activity. Our findings indicated that PAHs are still likely to have carcinogenic activity in indoor environments and exposure risk of children to indoor dust should be emphasized.
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