Tissue-resident memory T cells in tumor immunity and immunotherapy

Tissue-resident memory T cells (TRM) represent a heterogeneous T cell population with the functionality of both effector and memory T cells. TRM express residence gene signatures. This feature allows them to traffic to, reside in, and potentially patrol peripheral tissues, thereby enforcing an efficient long-term immune-protective role. Recent studies have revealed TRM involvement in tumor immune responses. TRM tumor infiltration correlates with enhanced response to current immunotherapy and is often associated with favorable clinical outcome in patients with cancer. Thus, targeting TRM may lead to enhanced cancer immunotherapy efficacy. Here, we review and discuss recent advances on the nature of TRM in the context of tumor immunity and immunotherapy. Tissue-resident memory T cells (TRM) reside in peripheral tissues, patrol their surroundings, and rapidly respond to alarming signals (Jiang et al., 2012; Schenkel et al., 2014; Park and Kupper, 2015; Clark, 2015; Dijkgraaf et al., 2019). These features enable them to potentially serve as critical players in antitumor surveillance and immunity. Early studies in viral infections have revealed that T cells were retained in tissues, including human and murine skin as well as murine small intestine and lung

Automated summary

Tissue-resident memory T cells (TRM) reside in peripheral tissues, patrol their surroundings, and rapidly respond to alarming signals. These features enable them to potentially serve as critical players in antitumor surveillance and immunity.