Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 218, Issue 6, Pages -Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20210518
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Categories
Funding
- Agence Nationale de la Recherche-Projets blancs
- Agence Nationale de la Recherche
- Association pour la Recherche sur le Cancer
- Canceropole Ile de France
- Chancellerie des Universites de Paris (Legs Poix)
- European Research Area Network on Cardiovascular Diseases (MINOTAUR)
- Fondation Carrefour
- Gustave Roussy Odyssea
- European Union Horizon 2020 Framework Programme Project Oncobiome
- High-end Foreign Expert Program in China [GDW20171100085, GDW20181100051]
- Institut National de la Sante et de la Recherche Medicale (Heterogeneity of Tumors Ecosystem)
- Institut National du Cancer
- Institut Universitaire de France
- LabEx Immuno-Oncology
- LeDucq Foundation
- Ligue Contre le Cancer (equipe labellisee)
- Recherche Hospitalo-Universitaire Torino Lumiere
- Seerave Foundation
- SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination
- SIRIC Cancer Research and Personalized Medicine
- Fondation pour la Recherche Medicale
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Ferroptosis is a form of regulated cell death triggered by iron toxicity, lipid peroxidation, and plasma membrane damage, and plays a role in shaping the immune response in health and disease.
Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity, lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis can be divided into two categories (biological versus chemical) and activate two major pathways (the extrinsic/transporter versus the intrinsic/enzymatic pathways). Excessive or deficient ferroptotic cell death is implicated in a growing list of physiological and pathophysiological processes, coupled to a dysregulated immune response. This review focuses on new discoveries related to how ferroptotic cells and their spilled contents shape innate and adaptive immunity in health and disease. Understanding the immunological characteristics and activity of ferroptotic death not only illuminates an intersection between cell death and immunity but may also lead to the development of novel treatment approaches for immunopathological diseases.
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