SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?

Article Immunology

Multi-inflammatory Syndrome in Children Related to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Spain

Cinta Moraleda et al.

Summary: Clusters of children with MIS-C associated with SARS-CoV-2 infection have been reported in Spain. MIS-C is a potentially severe condition that presents in children with recent SARS-CoV-2 infection.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Pediatrics

Hyperinflammatory shock related toCOVID-19 in a patient presenting with multisystem inflammatory syndrome in children: First case from Iran

Ahmad Bahrami et al.

JOURNAL OF PAEDIATRICS AND CHILD HEALTH (2021)

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Article Pediatrics

Longitudinal Echocardiographic Assessment of Coronary Arteries and Left Ventricular Function following Multisystem Inflammatory Syndrome in Children

Simone Jhaveri et al.

Summary: This study presents the short-term outcomes of cardiac dysfunction and coronary artery dilation in children with severe acute respiratory syndrome coronavirus disease-2-related multisystem inflammatory syndrome through a longitudinal echocardiographic single-center study involving 15 children.

JOURNAL OF PEDIATRICS (2021)

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Review Pediatrics

Multi-system inflammatory syndrome in children & adolescents (MIS-C): A systematic review of clinical features and presentation

Trisha Radia et al.

Summary: MIS-C, associated with Covid-19, shows higher incidence of gastrointestinal symptoms and severity, with the majority of cases requiring intensive care support.

PAEDIATRIC RESPIRATORY REVIEWS (2021)

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Article Cardiac & Cardiovascular Systems

Multimodality cardiac evaluation in children and young adults with multisystem inflammation associated with COVID-19

Paraskevi Theocharis et al.

Summary: This study utilized multimodality imaging to describe the cardiac involvement in a new multisystem inflammatory condition following the peak of the UK COVID-19 epidemic in young people. The findings revealed common pancarditis with cardiac dysfunction, myocardial oedema, and coronary artery dilatation, highlighting the need for close monitoring due to the risk of thrombotic myocardial infarction.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING (2021)

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Letter Pediatrics

Low-Dose Dexamethasone Following IVIG in Pediatric Inflammatory Multisystem Syndrome in Temporal Association with COVID-19 (PIMS-TC)

Priyanka Meena et al.

INDIAN JOURNAL OF PEDIATRICS (2021)

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Letter Pediatrics

Multisystem Inflammatory Syndrome in Children Associated with COVID 19 Treated with Oral Steroid

Mukesh Kumar Jain et al.

INDIAN JOURNAL OF PEDIATRICS (2021)

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Letter Pediatrics

Neurological Manifestations in Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS)

Sagar S. Lad et al.

INDIAN JOURNAL OF PEDIATRICS (2021)

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Article Genetics & Heredity

Association of an IGHV3-66 gene variant with Kawasaki disease

Todd A. Johnson et al.

Summary: The study identified a significant association between SNVs in the IGHV cluster and susceptibility to Kawasaki disease (KD). Furthermore, they observed highly skewed allelic usage in relation to a specific gene in the IGHV cluster, suggesting potential B-cell related mechanisms in the pathogenesis of KD. This association may shed light on common mechanisms between KD, acute rheumatic fever (ARF), and rheumatic heart disease (RHD).

JOURNAL OF HUMAN GENETICS (2021)

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Review Pediatrics

A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process

Rachel Harwood et al.

Summary: PIMS-TS is a newly discovered condition associated with COVID-19, and a national consensus management pathway has been developed for UK clinicians caring for affected children. The guidance emphasizes the importance of a multidisciplinary team in decision-making and recommends treatment options including supportive care, immunoglobulin, steroids, and biological therapies. This guidance provides a solid framework for clinicians caring for children with PIMS-TS in the UK and will be updated based on future evidence.

LANCET CHILD & ADOLESCENT HEALTH (2021)

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Review Cardiac & Cardiovascular Systems

Review of Cardiac Involvement in Multisystem Inflammatory Syndrome in Children

Tarek Alsaied et al.

Summary: Multisystem inflammatory syndrome in children, triggered by SARS-CoV-2 infection, is a severe inflammatory disease with common symptoms of persistent fever and cardiac manifestations. Treatment mainly aims at reversing the inflammatory response with immunomodulatory medications.

CIRCULATION (2021)

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Article Cardiac & Cardiovascular Systems

Acute Cardiovascular Manifestations in 286 Children With Multisystem Inflammatory Syndrome Associated With COVID-19 Infection in Europe

Israel Valverde et al.

Summary: The study documented cardiovascular clinical findings, cardiac imaging, and laboratory markers in children with multisystem inflammatory syndrome associated with COVID-19 infection. Most children in the study cohort had cardiac complications and significantly raised levels of inflammatory markers.

CIRCULATION (2021)

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Editorial Material Medical Laboratory Technology

Gastrointestinal Symptoms Followed by Shock in a Febrile 7-Year-Old Child during the COVID-19 Pandemic

Slimane Allali et al.

CLINICAL CHEMISTRY (2021)

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Article Immunology

Distinctive Features of Kawasaki Disease Following SARS-CoV-2 Infection: a Controlled Study in Paris, France

Julie Toubiana et al.

Summary: During the COVID-19 pandemic, there was an increase in multisystem inflammatory syndrome in children, including Kawasaki disease. Research showed that children with KD associated with confirmed SARS-CoV-2 infection were more likely to be of sub-Saharan African ancestry, older, exhibit more gastrointestinal and neurological symptoms, shock syndrome, and myocarditis compared to those with classic KD. These findings highlight the need for further investigation into the pathogenesis of KD-SARS-CoV-2.

JOURNAL OF CLINICAL IMMUNOLOGY (2021)

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Article Pediatrics

Time Course of Coronary Artery Aneurysms in Kawasaki Disease

Etsuko Tsuda et al.

Summary: The timing for coronary artery aneurysms (CAAs) caused by Kawasaki disease to reach their maximum diameter and regress vary, with smaller CAAs regressing earlier. Most CAAs with a diameter of less than 6mm regress within 6 months after Kawasaki disease.

JOURNAL OF PEDIATRICS (2021)

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Article Pediatrics

Multisystem Inflammatory Syndrome in Children: An International Survey

Carles Bautista-Rodriguez et al.

Summary: An international survey on children diagnosed with multisystem inflammatory syndrome temporally associated with SARS-CoV-2 showed a wide clinical spectrum, including Kawasaki disease-like cases, life-threatening shock, and milder cases with mainly fever and inflammation. A shorter duration of symptoms before admission was associated with a worse outcome.

PEDIATRICS (2021)

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Article Pediatrics

Case Report: Case Series of Children With Multisystem Inflammatory Syndrome Following SARS-CoV-2 Infection in Switzerland

Athina Fouriki et al.

Summary: Clinical case series showed that most Swiss children with MIS-C presented with clinical features compatible with Incomplete KD and Toxic Shock Syndrome, with high IL-1RA levels. Anakinra is suggested as an alternative to steroids in these children.

FRONTIERS IN PEDIATRICS (2021)

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Article Infectious Diseases

A case series of children and young people admitted to a tertiary care hospital in Germany with COVID-19

Jonathan Remppis et al.

Summary: While most cases of COVID-19 in children are mild, severe respiratory illness and multisystem inflammatory syndrome (MIS-C) can occur, sometimes with fatal outcomes. Children with underlying diseases may be at a higher risk for severe illness.

BMC INFECTIOUS DISEASES (2021)

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Article Rheumatology

Multisystem inflammatory syndrome in children during the COVID-19 pandemic in Turkey: first report from the Eastern Mediterranean

Yasemin Ozsurekci et al.

Summary: The study found that MIS-C patients have longer duration of fever, higher rates of rash, conjunctival injection, peripheral edema, abdominal pain, altered mental status, and myalgia, with 53.3% of cases showing evidence of myocardial involvement. Corticosteroids, intravenous immunoglobulin, and biologic immunomodulatory treatments were commonly used in MIS-C cases compared to severe COVID-19 cases. It is concluded that MIS-C may be a distinct immunopathogenic disease, with conjunctival injection, higher CRP, and low WBC count being reliable diagnostic parameters for MIS-C cases.

CLINICAL RHEUMATOLOGY (2021)

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Article Medicine, General & Internal

Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children

Naim Ouldali et al.

Summary: Among children with MIS-C, treatment with IVIG and methylprednisolone compared to IVIG alone was associated with a more favorable fever course, reduced risk of needing second-line therapy, hemodynamic support, acute left ventricular dysfunction after initial therapy, and shorter stay in the pediatric intensive care unit. The study interpretation is limited by its observational design.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Article Immunology

Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine

Paul Bastard et al.

Summary: In rare cases, yellow fever virus (YFV) live attenuated vaccine can cause life-threatening disease, particularly in patients with no history of severe viral illness. Some patients with auto-Abs against multiple type I interferons and autosomal recessive IFNAR1 or IFNAR2 deficiency were found to be at risk of developing severe complications after YFV vaccination. Testing for these predispositions could be considered for healthy individuals before YFV vaccination.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Letter Pediatrics

ACUTE APPENDICITIS MIMICKING MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN: CASE REPORT AND REVIEW OF THE LITERATURE

Zahraa Al Lawati et al.

JOURNAL OF PAEDIATRICS AND CHILD HEALTH (2021)

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Article Immunology

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19

Laura A. Vella et al.

Summary: Pediatric COVID-19 following SARS-CoV-2 infection in children is generally less severe than in adults, but the subset of children with MIS-C exhibit immune features similar to severely ill adults and vascular complications. MIS-C patients show robust activation of T cells and vascular patrolling cells, correlating with the use of vasoactive medication. Unlike pediatric COVID-19 patients with ARDS, MIS-C patients display clinical improvement over time along with decreasing immune activation.

SCIENCE IMMUNOLOGY (2021)

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Article Pediatrics

Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance

Chris Gale et al.

Summary: This study aimed to describe the incidence, characteristics, transmission, and outcomes of SARS-CoV-2 infection in neonates who received inpatient hospital care in the UK. The findings showed that neonatal SARS-CoV-2 infection was uncommon in babies admitted to hospital, with low likelihood of infection following birth to a mother with perinatal SARS-CoV-2 infection and rare possible vertical transmission. The high proportion of babies from Black, Asian, or minority ethnic groups requires further investigation.

LANCET CHILD & ADOLESCENT HEALTH (2021)

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Article Pediatrics

Multisystem inflammatory syndrome in children (MIS-C) during SARS-CoV-2 pandemic in Brazil: a multicenter, prospective cohort study

Fernanda Lima-Setta et al.

Summary: This study described the clinical, laboratory, and radiological characteristics of children with MIS-C, and found that most patients had similar features to other cohorts. Long-term multidisciplinary follow-up is needed to observe if chronic cardiac impairment or other sequelae may occur in these patients.

JORNAL DE PEDIATRIA (2021)

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Article Medicine, Research & Experimental

Similarities and differences between the immunopathogenesis of COVID-19-related pediatric multisystem inflammatory syndrome and Kawasaki disease

Ana Esteve-Sole et al.

Summary: Research findings suggest that circulating cytokines are significantly elevated in patients with MIS-C and KD, with IFN-gamma-induced response markers and inflammatory monocyte activation markers being the main triggers of inflammation. A subgroup of MIS-C patients (MIS-C-plus) showed differentiation from other MIS-C patients in certain cytokines, indicating incipient signs of macrophage activation syndrome.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Infectious Diseases

Immunological Assessment of Pediatric Multisystem Inflammatory Syndrome Related to Coronavirus Disease 2019

Serge Grazioli et al.

Summary: This study reported 4 pediatric patients with MIS-C related to COVID-19, showing a postinfectious inflammatory syndrome with elevation in all cytokines, and markers of recent T-cell activation. While some features overlap with HLH, the patients in this study exhibited different perforin expression and NK cell degranulation compared to primary HLH cases.

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY (2021)

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Article Infectious Diseases

Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Antibody Responses in Children With Multisystem Inflammatory Syndrome in Children (MIS-C) and Mild and Severe Coronavirus Disease 2019 (COVID-19)

Elizabeth M. Anderson et al.

Summary: Pediatric patients with MIS-C have higher SARS-CoV-2 spike IgG titers, possibly indicating a longer time since infection onset.

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY (2021)

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Review Pediatrics

Multisystem inflammatory syndrome in children related to COVID-19: An update regarding the presentation of two critically ill patients

Pedro Taffarel et al.

Summary: Multisystem inflammatory syndrome in children related to COVID-19 is characterized by persistent fever, inflammation, and organ dysfunction, with exclusion of other microbial causes. It shares similarities with other inflammatory diseases and hypercytokinemia conditions, but differs in clinical presentation and laboratory parameters. Treatment options include intravenous immunoglobulin and systemic corticosteroids.

ARCHIVOS ARGENTINOS DE PEDIATRIA (2021)

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Article Infectious Diseases

COVID-19-Related Giant Coronary Aneurysms in an Infant with Multisystem Inflammatory Disorder in Children: The First Case Report from the United Arab Emirates and the Arab Region

Ghassan Ghatasheh et al.

Summary: Multisystem inflammatory disorder in children and adolescents is a rare complication of COVID-19 that seems to develop post-infection, resembling Kawasaki disease. This report presents a case of a nine-month-old infant meeting the criteria for MIS-C, who responded well to treatment.

CASE REPORTS IN INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

The Importance of Early Recognition, Timely Management, and the Role of Healthcare Providers in Multisystem Inflammatory Syndrome in Children

Ji-Hyuk Lee et al.

Summary: This case study describes a 12-year-old boy who developed MIS-C approximately three weeks after a confirmed diagnosis of COVID-19. The initial symptoms of MIS-C were high fever with abdominal pain mimicking appendicitis. The patient fully recovered without any obvious sequelae after receiving two doses of intravenous immunoglobulin five days after the onset of MIS-C. Early recognition and prompt management are crucial in saving the lives of children affected by MIS-C.

JOURNAL OF KOREAN MEDICAL SCIENCE (2021)

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Review Hematology

Primary immunodeficiencies reveal the molecular requirements for effective host defense against EBV infection

Stuart G. Tangye et al.

BLOOD (2020)

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Review Hematology

Pediatric hemophagocytic lymphohistiocytosis

Scott W. Canna et al.

BLOOD (2020)

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Letter Immunology

Systemic Inflammation and Myelofibrosis in a Patient with Takenouchi-Kosaki Syndrome due to CDC42 Tyr64Cys Mutation

Giorgia Bucciol et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2020)

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Article Immunology

A Protein Epitope Targeted by the Antibody Response to Kawasaki Disease

Anne H. Rowley et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Pathology

Lethal Infectious Diseases as Inborn Errors of Immunity: Toward a Synthesis of the Germ and Genetic Theories

Jean-Laurent Casanova et al.

Annual Review of Pathology-Mechanisms of Disease (2020)

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Editorial Material Biochemistry & Molecular Biology

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

Jean-Laurent Casanova et al.

CELL (2020)

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Article Cardiac & Cardiovascular Systems

Acute Heart Failure in Multisystem Inflammatory Syndrome in Children in the Context of Global SARS-CoV-2 Pandemic

Zahra Belhadjer et al.

CIRCULATION (2020)

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Review Immunology

A framework for understanding Kawasaki disease pathogenesis

Mindy S. Lo

CLINICAL IMMUNOLOGY (2020)

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Article Allergy

Immunogenetics of Kawasaki disease

Rajni Kumrah et al.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2020)

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Editorial Material Genetics & Heredity

The human genetic determinism of life-threatening infectious diseases: genetic heterogeneity and physiological homogeneity?

Jean-Laurent Casanova et al.

HUMAN GENETICS (2020)

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Article Allergy

Type I IFN immunoprofiling in COVID-19 patients

Sophie Trouillet-Assant et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

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Editorial Material Immunology

The Growing Spectrum of Human Diseases Caused by Inherited CDC42 Mutations

Helen C. Su et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2020)

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Article Pediatrics

Epidemiology, Treatments, and Cardiac Complications in Patients with Kawasaki Disease: The Nationwide Survey in Japan, 2017-2018

Ryusuke Ae et al.

JOURNAL OF PEDIATRICS (2020)

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Article Medicine, General & Internal

Features of 20133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

Annemarie B. Docherty et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Letter Dermatology

Erythema multiforme and Kawasaki disease associated with COVID-19 infection in children

P. Labe et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

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Editorial Material Medicine, General & Internal

Kawasaki-like disease: emerging complication during the COVID-19 pandemic

Russell M. Viner et al.

LANCET (2020)

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Article Medicine, General & Internal

Hyperinflammatory shock in children during COVID-19 pandemic

Shelley Riphagen et al.

LANCET (2020)

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Article Medicine, General & Internal

An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study

Lucio Verdoni et al.

LANCET (2020)

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Article Pediatrics

SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children

Francesco Licciardi et al.

PEDIATRICS (2020)

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Article Rheumatology

Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort

Marie Pouletty et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Letter Dermatology

Dermatological manifestation of pediatrics multisystem inflammatory syndrome associated withCOVID-19 in a3-year-oldgirl

Can Yilmaz Yozgat et al.

DERMATOLOGIC THERAPY (2020)

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Article Infectious Diseases

SARS-CoV-2-related paediatric inflammatory multisystem syndrome, an epidemiological study, France, 1 March to 17 May 2020

Alexandre Belot et al.

EUROSURVEILLANCE (2020)

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Editorial Material Gastroenterology & Hepatology

Gastrointestinal Symptoms as a Major Presentation Component of a Novel Multisystem Inflammatory Syndrome in Children That Is Related to Coronavirus Disease 2019: A Single Center Experience of 44 Cases

Jonathan Miller et al.

GASTROENTEROLOGY (2020)

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Article Biochemistry & Molecular Biology

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

Mehdi Bouhaddou et al.

CELL (2020)

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Editorial Material Dermatology

Focus on COVID Toes

Claudia Hernandez et al.

JAMA DERMATOLOGY (2020)

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Article Clinical Neurology

Neurologic and Radiographic Findings Associated With COVID-19 Infection in Children

Omar Abdel-Mannan et al.

JAMA NEUROLOGY (2020)

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Article Rheumatology

American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 1

Lauren A. Henderson et al.

ARTHRITIS & RHEUMATOLOGY (2020)

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Article Immunology

Case Report: Systemic Inflammatory Response and Fast Recovery in a Pediatric Patient With COVID-19

Adam Klocperk et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Public, Environmental & Occupational Health

COVID-19-Associated Multisystem Inflammatory Syndrome in Children - United States, March-July 2020

Shana Godfred-Cato et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2020)

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Article Medicine, General & Internal

Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2

Elizabeth Whittaker et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Letter Medicine, General & Internal

Multisystem Inflammatory Syndrome Related to COVID-19 in Previously Healthy Children and Adolescents in New York City

Eva W. Cheung et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Editorial Material Medicine, General & Internal

SARS-CoV-2-Related Inflammatory Multisystem Syndrome in Children Different or Shared Etiology and Pathophysiology as Kawasaki Disease?

Brian W. McCrindle et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Medicine, General & Internal

Multisystem Inflammatory Syndrome With Complete Kawasaki Disease Features Associated With SARS-CoV-2 Infection in a Young Adult. A Case Report

Elie Cogan et al.

FRONTIERS IN MEDICINE (2020)

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Article Pediatrics

Emergence of Kawasaki disease related to SARS-CoV-2 infection in an epicentre of the French COVID-19 epidemic: a time-series analysis

Naim Ouldali et al.

LANCET CHILD & ADOLESCENT HEALTH (2020)

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Article Pediatrics

COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study

Florian Goetzinger et al.

LANCET CHILD & ADOLESCENT HEALTH (2020)

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Article Pediatrics

Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study

Patrick Davies et al.

LANCET CHILD & ADOLESCENT HEALTH (2020)

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Letter Pediatrics

Multisystem inflammatory syndrome associated with COVID-19 in children in Pakistan

Masood Sadiq et al.

LANCET CHILD & ADOLESCENT HEALTH (2020)

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Article Virology

COVID-19 multisystem inflammatory syndrome in three teenagers with confirmed SARS-CoV-2 infection

Khuen Foong Ng et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

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Article Pediatrics

Characteristics, Cardiac Involvement, and Outcomes of Multisystem Inflammatory Disease of Childhood (MIS-C) Associated with SARS-CoV-2 Infection

Christine A. Capone et al.

JOURNAL OF PEDIATRICS (2020)

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Review Pediatrics

Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2: A Systematic Review

Joseph Y. Abrams et al.

JOURNAL OF PEDIATRICS (2020)

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Editorial Material Medicine, General & Internal

Pediatric inflammatory multisystem syndrome temporally associated with COVID-19: a spectrum of diseases with many names

Herman Tam et al.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2020)

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Article Biochemistry & Molecular Biology

The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19

Camila Rosat Consiglio et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C)

Conor N. Gruber et al.

CELL (2020)

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Article Medicine, General & Internal

Multisystem Inflammatory Syndrome in US Children and Adolescents

Leora R. Feldstein et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Multisystem Inflammatory Syndrome in Children in New York State

Elizabeth M. Dufort et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Cardiac & Cardiovascular Systems

Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital

Tristan Ramcharan et al.

PEDIATRIC CARDIOLOGY (2020)

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Letter Immunology

Cytokine Profile in an Adolescent With Pediatric Multisystem Inflammatory Syndrome Temporally Related to COVID-19

Danilo Buonsenso et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2020)

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Article Immunology

Pediatric Inflammatory Multisystem Syndrome With Central Nervous System Involvement and Hypocomplementemia Following SARS-COV-2 Infection

Tslil Regev et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2020)

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Article Radiology, Nuclear Medicine & Medical Imaging

Cardiac MRI in Children with Multisystem Inflammatory Syndrome Associated with COVID-19

Eleonore Blondiaux et al.

RADIOLOGY (2020)

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Article Medicine, General & Internal

Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study

Julie Toubiana et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Letter Medicine, General & Internal

Covid-19 in Peru: from supervised walks for children to the first case of Kawasaki-like syndrome

Jaime A. Yanez et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Article Medicine, Research & Experimental

Distinct clinical and immunological features of SARS-CoV-2-induced multisystem inflammatory syndrome in children

Pui Y. Lee et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Medicine, Research & Experimental

Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS CoV-2

Caroline Diorio et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Review Emergency Medicine

MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN (MIS-C) IN AN ADOLESCENT THAT DEVELOPED CORONARY ANEURYSMS: A CASE REPORT AND REVIEW OF THE LITERATURE

Cole Nelson et al.

JOURNAL OF EMERGENCY MEDICINE (2020)

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Editorial Material Cardiac & Cardiovascular Systems

Cardiac Dysfunction in Multisystem Inflammatory Syndrome in Children A Call to Action

Kevin G. Friedman et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Echocardiographic Findings in Pediatric Multisystem Inflammatory Syndrome Associated With COVID-19 in the United States

Daisuke Matsubara et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Editorial Material Cardiac & Cardiovascular Systems

The first case of pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS) in Poland, complicated by giant coronary artery aneurysms

Pawel Tracewski et al.

KARDIOLOGIA POLSKA (2020)

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Article Biochemistry & Molecular Biology

Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection

Michael J. Carter et al.

NATURE MEDICINE (2020)

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Letter Immunology

Acute Appendicitis in Multisystem Inflammatory Syndrome in Children With COVID-19

Juanita Lishman et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2020)

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Letter Immunology

Multisystem Inflammatory Syndrome Surveillance and COVID-19 in Latin America

Rolando Ulloa-Gutierrez et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2020)

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Article Immunology

Multisystem Inflammatory Syndrome Associated With Coronavirus Disease in Children A Multi-centered Study in Belem, Para, Brazil

Emmerson C. F. de Farias et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2020)

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Article Multidisciplinary Sciences

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation

Mary Hongying Cheng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Multidisciplinary Sciences

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Qian Zhang et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Paul Bastard et al.

SCIENCE (2020)

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Article Medicine, General & Internal

Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study

Olivia Swann et al.

BMJ-BRITISH MEDICAL JOURNAL (2020)

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Article Cardiac & Cardiovascular Systems

Cardiac Abnormalities Seen in Pediatric Patients During the SARS-CoV2 Pandemic: An International Experience

Bradley C. Clark et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

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Article Public, Environmental & Occupational Health

Case Series of Multisystem Inflammatory Syndrome in Adults Associated with SARS-CoV-2 Infection - United Kingdom and United States, March-August 2020

Sapna Bamrah Morris et al.

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