4.5 Review

Rhododendrol-induced leukoderma update II: Pathophysiology, mechanisms, risk evaluation, and possible mechanism-based treatments in comparison with vitiligo

Journal

JOURNAL OF DERMATOLOGY
Volume 48, Issue 7, Pages 969-978

Publisher

WILEY
DOI: 10.1111/1346-8138.15878

Keywords

leukoderma; melanocyte; oxidative stress; rhododendrol; vitiligo

Categories

Funding

  1. Kanebo Cosmetics Inc.

Ask authors/readers for more resources

This review examines the major considerations for developing rhododendrol-induced leukoderma, providing a wide range of information on pathophysiology, mechanisms, risk evaluation, and potential treatments. The review discusses cytotoxicity of rhododendrol, cytoprotective functions, involvement of the immune system, and potential novel treatments, addressing individual differences and the mechanisms underlying the condition. Understanding rhododendrol-induced leukoderma not only sheds light on the mechanisms of non-segmental vitiligo, but also suggests possible prevention and treatment strategies.
A small proportion of individuals utilizing cosmetics containing rhododendrol developed leukoderma with various pathological conditions, in some cases indistinguishable from vitiligo. In this review, we investigate and evaluate the major considerations for developing rhododendrol-induced leukoderma based on data from original or review articles published in the literature to provide a wide range of information regarding the pathophysiology, mechanisms, risk evaluation, and possible mechanism-based treatments. We compile and discuss the latest information, including data related to the cytotoxicity of rhododendrol, cytoprotective functions, and involvement of the immune system, and consider the possibility of novel treatments based on the differences between individual patients and on the mechanism underlying the onset of the condition. Understanding the pathophysiology of rhododendrol-induced leukoderma helps not only elucidate the mechanisms of non-segmental vitiligo onset and progression, but also suggests prevention and treatment.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available